肾移植受者的妊娠结局：环孢素A的影响。

Pregnancy outcome in renal allograft recipients: influence of ciclosporin A.

作者信息

Haugen G, Fauchald P, Sødal G, Halvorsen S, Oldereid N, Moe N

机构信息

Department of Obstetrics and Gynecology, National Hospital, Oslo, Norway.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1991 Mar 21;39(1):25-9. doi: 10.1016/0028-2243(91)90137-a.

DOI:10.1016/0028-2243(91)90137-a

PMID:2029952

Abstract

The outcome of 35 pregnancies in 26 renal allograft recipients is reported. Twenty-four pregnancies in patients treated with prednisolone and azathioprine resulted in 22 live-born infants (one twin pregnancy) and 3 induced abortions on medical indications. Three of the deliveries were preterm, and one of the infants had a birth weight below the 2.5th percentile. Ten patients (11 pregnancies) were treated with ciclosporin A (CsA). These women delivered 5 infants (3 preterm deliveries of whom the birth weight of one infant was below the 5th percentile) and underwent 3 induced (medical indications) and 3 spontaneous abortions. Mean birth weight in the CsA treated group was 2464 g (range 1790-2930 g), and their gestational age varied from 232 to 271 days. No foetal malformations were observed in the two groups. The results may indicate a harmful effect of CsA on pregnancy outcome.

摘要

报告了26例肾移植受者的35次妊娠结局。接受泼尼松龙和硫唑嘌呤治疗的患者中有24次妊娠，产下22名活产婴儿（1例双胎妊娠），并有3例因医学指征而引产。其中3例分娩为早产，1例婴儿出生体重低于第2.5百分位数。10名患者（11次妊娠）接受了环孢素A（CsA）治疗。这些女性产下5名婴儿（3例早产，其中1例婴儿出生体重低于第5百分位数），并进行了3例引产（医学指征）和3例自然流产。CsA治疗组的平均出生体重为2464克（范围1790 - 2930克），孕周从232天到271天不等。两组均未观察到胎儿畸形。结果可能表明CsA对妊娠结局有有害影响。