心外膜-心肌信号指导冠状动脉血管发生。
Epicardial-myocardial signaling directing coronary vasculogenesis.
机构信息
Section of Cardiology, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA.
出版信息
Circ Res. 2010 Mar 19;106(5):818-32. doi: 10.1161/CIRCRESAHA.109.209197.
Abstract
The establishment of the coronary circulation is critical for the development of the embryonic heart. Over the last several years, there has been tremendous progress in elucidating the pathways that control coronary development. Interestingly, many of the pathways that regulate the development of the coronary vasculature are distinct from those governing vasculogenesis in the rest of the embryo. It is becoming increasingly clear that coronary development depends on a complex communication between the epicardium, the subepicardial mesenchyme, and the myocardium mediated in part by secreted growth factors. This communication coordinates the growth of the myocardium with the formation of the coronary vasculature. This review summarizes our present understanding of the role of these growth factors in the regulation of coronary development. Continued progress in this field holds the potential to lead to novel therapeutics for the treatment of patients with coronary artery disease.
摘要
冠状动脉的建立对于胚胎心脏的发育至关重要。在过去的几年中，阐明控制冠状动脉发育的途径方面取得了巨大进展。有趣的是，许多调节冠状动脉血管生成的途径与调节胚胎其他部位血管生成的途径不同。越来越明显的是，冠状动脉的发育依赖于心外膜、心外膜下间充质和心肌之间的复杂通讯，部分由分泌的生长因子介导。这种通讯协调了心肌的生长和冠状动脉的形成。这篇综述总结了我们目前对这些生长因子在调节冠状动脉发育中的作用的理解。该领域的持续进展有可能为治疗冠状动脉疾病患者带来新的治疗方法。
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