Leahey Tricia M, Myers Taryn A, Gunstad John, Glickman Ellen, Spitznagel Mary Beth, Alexander Thomas, Juvancic-Heltzel Judi
Department of Psychology, Kent State University, Kent, OH 44240, USA.
Nutr Neurosci. 2007 Oct-Dec;10(5-6):205-9. doi: 10.1080/10284150701676156.
Body composition and obesity-related lifestyle factors are associated with increased risk for Alzheimer's disease (AD). Amyloid beta (Abeta) is a peptide integral in the pathogenesis of AD. Abeta has been shown to be related to body fat and exercise in younger adults; however, no study to date has examined the possible relationship among Abeta, body composition and fitness indices in older adults.
Thirty-five older adults without significant neurological or psychiatric history, underwent fasting blood draw and completed cognitive testing and body composition and physical fitness assessments.
Partial correlations showed Abeta levels were inversely related to cognitive function, body fat and physical fitness measures.
Findings indicate Abeta is associated with cognitive function, body fat and physical fitness in neurologically healthy older adults. Further work is needed to clarify possible mechanisms, particularly longitudinal studies.
身体成分和与肥胖相关的生活方式因素与患阿尔茨海默病（AD）的风险增加有关。β-淀粉样蛋白（Aβ）是AD发病机制中的一种重要肽段。在较年轻的成年人中，Aβ已被证明与体脂和运动有关；然而，迄今为止尚无研究探讨老年人中Aβ、身体成分和健康指数之间的可能关系。
35名无重大神经或精神病史的老年人接受了空腹采血，并完成了认知测试、身体成分和体能评估。
偏相关性分析显示，Aβ水平与认知功能、体脂和体能指标呈负相关。
研究结果表明，在神经健康的老年人中，Aβ与认知功能、体脂和体能有关。需要进一步开展工作以阐明可能的机制，尤其是纵向研究。
