染色体区域。
Chromosome territories.
机构信息
Biozentrum, Department of Biology II, Ludwig-Maximilians-University, Grosshadernerstrasse 2, 82152 Martinsried, Germany.
出版信息
Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a003889. doi: 10.1101/cshperspect.a003889.
Abstract
Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief statement, the possible contribution of nuclear architecture studies to the field of epigenomics is considered, followed by a historical account of the CT concept and the final compelling experimental evidence of a territorial organization of chromosomes in all eukaryotes studied to date. Present knowledge of nonrandom CT arrangements, of the internal CT architecture, and of structural interactions with other CTs is provided as well as the dynamics of CT arrangements during cell cycle and postmitotic terminal differentiation. The article concludes with a discussion of open questions and new experimental strategies to answer them.
摘要
染色体区域（CTs）构成了核架构的主要特征。简要介绍了核架构研究对表观基因组学领域的可能贡献，接着回顾了 CT 概念的历史，并最终提供了迄今为止在所有已研究真核生物中染色体具有区域性组织的有力实验证据。本文还介绍了非随机 CT 排列、内部 CT 结构以及与其他 CT 的结构相互作用的知识，以及 CT 在细胞周期和有丝分裂后终末分化过程中的动态变化。文章最后讨论了悬而未决的问题和新的实验策略来回答这些问题。
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