Silver A J, Flood J F, Morley J E
GRECC, St. Louis Department of Veterans Affairs Medical Center.
J Gerontol. 1991 May;46(3):B117-21. doi: 10.1093/geronj/46.3.b117.
The amount of fluid consumed by C57BL/6Nnia male mice 3, 12, and 25 months of age under various paradigms was studied. The old mice consumed less water during the dark cycle but not during the light cycle (12 h lights off; 12 h lights on). When thirst was induced by providing dry food pellets or after overnight fluid deprivation, old mice consumed significantly less water than younger mice over a one-hour period. When thirst was induced by administration of hypertonic saline, there were no age-related effects. Naloxone 7.5 mg/kg IP significantly suppressed drinking in 3- and 12-month-old mice, while 25-month-old mice did not show suppression. Dehydration-induced thirst is impaired in old mice, as it is in older humans. This may be related to the alteration in opioid mechanisms modulating thirst.
研究了3个月、12个月和25个月大的C57BL/6Nnia雄性小鼠在各种模式下的液体摄入量。老年小鼠在黑暗周期中饮水量较少，但在光照周期（关灯12小时；开灯12小时）中饮水量与年轻小鼠无差异。当通过提供干食颗粒诱导口渴或在过夜禁水后，老年小鼠在1小时内的饮水量明显少于年轻小鼠。当通过注射高渗盐水诱导口渴时，未观察到与年龄相关的影响。腹腔注射7.5mg/kg纳洛酮可显著抑制3个月和12个月大的小鼠饮水，而25个月大的小鼠未表现出抑制作用。与老年人一样，老年小鼠脱水诱导的口渴功能受损。这可能与调节口渴的阿片类机制改变有关。
