Silver A J, Morley J E, Ishimaru-Tseng T V, Morley P M
Education and Clinical Center, St. Louis Department of Veterans Affairs, MO 63104.
Neurobiol Aging. 1993 Nov-Dec;14(6):519-22. doi: 10.1016/0197-4580(93)90033-8.
Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3, 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated with food deprivation than did 3-month-old rats. Three month old rats drank more fluid after angiotensin II than did 12-, 20-, and 24-month-old rats when expressed as fluid intake per kg body weight. These studies confirm that the rat is a reasonable model to study age-related hypodipsia.
对3、12、20和24月龄的Fischer 344/布朗挪威F1大鼠的液体摄入情况进行了研究。当在24小时内测量液体摄入量时，液体摄入出现了与年龄相关的减少。禁水后，24月龄和20月龄的大鼠比3月龄和12月龄的大鼠饮水量少。与3月龄大鼠相比，12、20和24月龄的大鼠因食物剥夺而导致的液体摄入量更少。当以每千克体重的液体摄入量表示时，3月龄大鼠在注射血管紧张素II后比12、20和24月龄的大鼠饮用更多的液体。这些研究证实，大鼠是研究与年龄相关的饮水减少的合理模型。
