Servizio Emodialisi, Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, 8-00168 Rome, Italy.
Gen Hosp Psychiatry. 2010 Mar-Apr;32(2):125-31. doi: 10.1016/j.genhosppsych.2009.10.009. Epub 2009 Dec 5.
Little is known about the demographic, clinical and laboratory variables which may be correlated with symptoms of depression and anxiety in hemodialysis (HD) patients. The present study aimed at evaluating such correlation in HD patients treated at a single HD center in a Mediterranean country.
Eighty HD patients were assessed for depression and anxiety with the Beck Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale (HARS). The scores of BDI and HARS were correlated with demographic, clinical and laboratory variables.
Based on the Beck Depression Inventory, 38 patients had no symptoms of depression and 42 had symptoms of depression. Based on the HARS, three patients had no symptoms of anxiety and 38 had mild symptoms of anxiety, whereas moderate or severe symptoms of anxiety were present in 39 patients. In univariate analysis, BDI score correlated significantly with age, the Charlson Comorbidity Index, SF-36 Vitality Subscale, Mini-Mental Status Examination, creatinine, albumin, plasma 25-hydroxy vitamin D and interleukin-6 (IL-6) levels. HARS score correlated significantly with age, Charlson Comorbidity Index, SF-36 Vitality Subscale and parathyroid hormone (PTH) levels. In the multivariate analysis, a direct and an inverse correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] was observed. With regard to HARS, only a direct correlation with Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)] was found.
Although numerous demographic, clinical and laboratory variables correlated with BDI and HARS in univariate analysis, the multivariate regression analysis showed only a direct correlation between BDI and IL-6 [P=.042, OR=1.31 (95% CI=1.01-1.71)] and an inverse correlation between BDI and creatinine [P=.050, OR=0.73 (95% CI=0.54-1.00)] and a direct correlation between HARS and the Charlson Comorbidity Index [P<.001, OR=1.55 (95% CI=1.22-1.96)].
关于可能与血液透析（HD）患者的抑郁和焦虑症状相关的人口统计学、临床和实验室变量，目前人们知之甚少。本研究旨在评估地中海国家单一 HD 中心治疗的 HD 患者中是否存在这种相关性。
使用贝克抑郁量表（BDI）和汉密尔顿焦虑量表（HARS）对 80 名 HD 患者进行抑郁和焦虑评估。BDI 和 HARS 的评分与人口统计学、临床和实验室变量相关。
根据贝克抑郁量表，38 名患者没有抑郁症状，42 名患者有抑郁症状。根据 HARS，3 名患者没有焦虑症状，38 名患者有轻度焦虑症状，而 39 名患者有中度或重度焦虑症状。在单因素分析中，BDI 评分与年龄、Charlson 合并症指数、SF-36 活力量表、简易精神状态检查、肌酐、白蛋白、血浆 25-羟维生素 D 和白细胞介素-6（IL-6）水平显著相关。HARS 评分与年龄、Charlson 合并症指数、SF-36 活力量表和甲状旁腺激素（PTH）水平显著相关。在多因素分析中，BDI 与 IL-6 之间存在直接和间接的相关性[P=.042，OR=1.31（95%CI=1.01-1.71）]和肌酐[P=.050，OR=0.73（95%CI=0.54-1.00）]。至于 HARS，仅与 Charlson 合并症指数呈直接相关[P<.001，OR=1.55（95%CI=1.22-1.96）]。
尽管在单因素分析中，许多人口统计学、临床和实验室变量与 BDI 和 HARS 相关，但多因素回归分析仅显示 BDI 与 IL-6 之间存在直接相关性[P=.042，OR=1.31（95%CI=1.01-1.71）]和 BDI 与肌酐之间存在间接相关性[P=.050，OR=0.73（95%CI=0.54-1.00）]，以及 HARS 与 Charlson 合并症指数之间存在直接相关性[P<.001，OR=1.55（95%CI=1.22-1.96）]。
