Faulkner A, Pollock H T
Hannah Research Institute, Ayr.
J Endocrinol. 1991 Apr;129(1):55-8. doi: 10.1677/joe.0.1290055.
The effects of i.v. glucagon-like peptide-1-(7-36)amide (GLP-1; 10 micrograms) on starved sheep given an i.v. glucose load (5 g) were studied. Plasma insulin concentrations rose significantly more after glucose administration in fed than in starved sheep. Giving GLP-1 to starved sheep increased the insulin response to the glucose load. The rise in plasma insulin concentrations in starved sheep given GLP-1 was similar to that observed in fed sheep. Plasma glucose concentrations returned to normal values more quickly in the starved sheep given GLP-1 than in starved sheep not given gut hormone. Plasma concentrations of free fatty acid, urea and alpha-amino nitrogen decreased more quickly following glucose administration in starved sheep given GLP-1 than in those not given GLP-1. The data suggest a role for GLP-1 in regulating plasma insulin concentrations and hence metabolism in ruminant animals. The possible role of gut hormones in ruminants is discussed.
研究了静脉注射胰高血糖素样肽-1-(7 - 36)酰胺（GLP - 1；10微克）对静脉注射葡萄糖负荷（5克）的饥饿绵羊的影响。与饥饿绵羊相比，喂食后的绵羊在给予葡萄糖后血浆胰岛素浓度显著升高更多。给饥饿绵羊注射GLP - 1可增强其对葡萄糖负荷的胰岛素反应。注射GLP - 1的饥饿绵羊血浆胰岛素浓度的升高与喂食绵羊中观察到的相似。注射GLP - 1的饥饿绵羊的血浆葡萄糖浓度比未给予肠激素的饥饿绵羊更快恢复到正常值。与未给予GLP - 1的饥饿绵羊相比，注射GLP - 1的饥饿绵羊在给予葡萄糖后血浆游离脂肪酸、尿素和α-氨基氮浓度下降得更快。数据表明GLP - 1在调节反刍动物血浆胰岛素浓度及由此调节代谢中发挥作用。讨论了肠激素在反刍动物中的可能作用。
