Wen Jiaqi, Guo Tao, Duanmu Xiaojie, Wu Chenqing, Wu Haoting, Zhou Cheng, Zheng Qianshi, Yuan Weijin, Qin Jianmei, Zhu Zihao, Wu Jingjing, Chen Jingwen, Xu Jingjing, Yan Yaping, Tian Jun, Zhang Baorong, He Hongjian, Zhang Minming, Guan Xiaojun, Xu Xiaojun
Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Joint Laboratory of Clinical Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
CNS Neurosci Ther. 2025 Mar;31(3):e70359. doi: 10.1111/cns.70359.
To investigate the gradients of nigrostriatal iron deposition in aging, Parkinson's disease (PD), and multiple system atrophy (MSA).
This study included 100 young healthy controls, 171 old healthy controls (OHC), 231 PD, and 24 MSA patients. The brain iron content was quantified by quantitative susceptibility mapping. A spatial function method was employed to map the iron gradient along the principal axis of the subcortical structure. General linear models were used to compare differences in iron gradients between groups. Partial correlation was used to analyze the relationship between iron content and symptoms of synucleinopathies.
Nigrostriatal iron deposition in all gradient directions was observed during aging (p < 0.05). Compared to OHC, iron deposition was significant in nearly all substantia nigra (SN) segments in both PD and MSA (p < 0.05). MSA showed significant iron deposition in the posterolateral putamen compared to PD (p < 0.05). Iron deposition in the SN in PD and putamen in MSA correlated with disease severity.
Iron deposition in all gradient directions occurred in the nigrostriatal system during healthy aging, and this was more evident in the SN in both PD and MSA, with MSA displaying additional iron deposition in the posterolateral putamen.
研究衰老、帕金森病（PD）和多系统萎缩（MSA）中黑质纹状体铁沉积的梯度变化。
本研究纳入100名年轻健康对照者、171名老年健康对照者（OHC）、231名PD患者和24名MSA患者。通过定量磁化率成像对脑铁含量进行量化。采用空间函数法绘制沿皮质下结构主轴的铁梯度图。使用一般线性模型比较各组之间铁梯度的差异。采用偏相关分析铁含量与突触核蛋白病症状之间的关系。
在衰老过程中，观察到所有梯度方向的黑质纹状体铁沉积（p < 0.05）。与OHC相比，PD和MSA中几乎所有黑质（SN）节段的铁沉积均显著（p < 0.05）。与PD相比，MSA在壳核后外侧显示出显著的铁沉积（p < 0.05）。PD中SN的铁沉积和MSA中壳核的铁沉积与疾病严重程度相关。
在健康衰老过程中，黑质纹状体系统在所有梯度方向均出现铁沉积，在PD和MSA的SN中更为明显，MSA在壳核后外侧还存在额外的铁沉积。
