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Membrane-binding and enzymatic properties of RPE65.
Prog Retin Eye Res. 2010 Sep;29(5):428-42. doi: 10.1016/j.preteyeres.2010.03.002. Epub 2010 Mar 19.
2
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.
3
Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.
Cell. 2005 Aug 12;122(3):449-59. doi: 10.1016/j.cell.2005.06.042.
4
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.
Biochem Biophys Res Commun. 2010 Jan 22;391(4):1757-61. doi: 10.1016/j.bbrc.2009.12.149. Epub 2009 Dec 30.
5
Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis.
J Neurosci. 2016 May 25;36(21):5808-19. doi: 10.1523/JNEUROSCI.3857-15.2016.
7
Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.
Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13658-63. doi: 10.1073/pnas.0504167102. Epub 2005 Sep 6.
8
Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.
9
Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina.
Methods Mol Biol. 2010;652:329-39. doi: 10.1007/978-1-60327-325-1_19.
10
RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model.
J Neurosci. 2011 Dec 14;31(50):18618-26. doi: 10.1523/JNEUROSCI.4265-11.2011.

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1
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65.
Life Sci Alliance. 2022 Oct 20;6(1). doi: 10.26508/lsa.202201546. Print 2023 Jan.
2
The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2115202119. doi: 10.1073/pnas.2115202119. Epub 2022 Mar 10.
3
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration.
Stem Cell Reports. 2022 Mar 8;17(3):448-458. doi: 10.1016/j.stemcr.2022.01.001. Epub 2022 Feb 3.
4
Retinal pigment epithelium 65 kDa protein (RPE65): An update.
Prog Retin Eye Res. 2022 May;88:101013. doi: 10.1016/j.preteyeres.2021.101013. Epub 2021 Oct 2.
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Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration.
iScience. 2021 Mar 29;24(4):102376. doi: 10.1016/j.isci.2021.102376. eCollection 2021 Apr 23.
6
Pathways and disease-causing alterations in visual chromophore production for vertebrate vision.
J Biol Chem. 2021 Jan-Jun;296:100072. doi: 10.1074/jbc.REV120.014405. Epub 2020 Nov 23.
8
Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs).
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158590. doi: 10.1016/j.bbalip.2019.158590. Epub 2019 Dec 23.
9
Structural biology of 11-retinaldehyde production in the classical visual cycle.
Biochem J. 2018 Oct 22;475(20):3171-3188. doi: 10.1042/BCJ20180193.
10
Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina.
PLoS One. 2017 Jul 3;12(7):e0180148. doi: 10.1371/journal.pone.0180148. eCollection 2017.

本文引用的文献

1
Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.
Prog Retin Eye Res. 2010 Sep;29(5):398-427. doi: 10.1016/j.preteyeres.2010.04.002. Epub 2010 Apr 24.
2
Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J Biol Chem. 2010 Mar 26;285(13):9667-9682. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.
3
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65.
Biochem Biophys Res Commun. 2010 Jan 22;391(4):1757-61. doi: 10.1016/j.bbrc.2009.12.149. Epub 2009 Dec 30.
5
Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
J Biol Chem. 2010 Jan 8;285(2):988-99. doi: 10.1074/jbc.M109.025643. Epub 2009 Nov 5.
6
Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.
7
Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):839-42. doi: 10.1107/S1744309109027535. Epub 2009 Jul 30.
8
Evidence for two retinoid cycles in the cone-dominated chicken eye.
Biochemistry. 2009 Jul 28;48(29):6854-63. doi: 10.1021/bi9002937.
9
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.
FEBS J. 2009 Jun;276(11):3020-30. doi: 10.1111/j.1742-4658.2009.07021.x. Epub 2009 Apr 20.
10
The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration.
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9625-30. doi: 10.1073/pnas.0904165106. Epub 2009 Jun 1.

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