INSTM and Laboratorio di Chimica per le Tecnologie, Università degli Studi di Brescia, Italy.
J Pharm Biomed Anal. 2010 Sep 5;52(5):787-90. doi: 10.1016/j.jpba.2010.02.030. Epub 2010 Mar 1.
An Indian patient referred to Clinica del Lavoro 'L.Devoto' of Milano showed clinical signs of heavy metal poisoning, possibly related to a sustained 6-month use of approx. 3 g/day of a traditional preparation (a whitish powder with a 'mineral' appearance) to treat urological problems. To confirm the causal relationship between the disease and the use of such product, metal testing was performed on the patient's hair and the ayurvedic remedy samples by total reflection X-ray fluorescence (TXRF). For TXRF analysis 1-cm cut of the patient's hair was directly deposited onto the quartz glass sample carrier, then 10 microl of nitric acid 65% were added and dried in air. TXRF showed high versatility, rapid and simultaneous element detection, and short analysis time, thus supporting a wider use in emergency medicine and in forensic analyses.
一位印度患者前往米兰的 Clinica del Lavoro 'L.Devoto' 就诊，表现出重金属中毒的临床症状，可能与持续使用约 3 克/天的传统制剂（一种外观呈白色粉末状的“矿物质”制剂）治疗泌尿科问题有关，该制剂已使用了 6 个月。为了确认疾病与使用该产品之间的因果关系，对患者的头发和阿育吠陀疗法样本进行了全反射 X 射线荧光（TXRF）金属测试。对于 TXRF 分析，直接将患者头发的 1 厘米切口沉积在石英玻璃样品载体上，然后加入 10 微升 65%的硝酸并在空气中干燥。TXRF 具有高度通用性、快速和同时的元素检测以及短的分析时间，因此支持在急诊医学和法医学分析中更广泛的应用。
