老年人 D-二聚体的相关因素。
Correlates of D-dimer in older persons.
机构信息
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
出版信息
Aging Clin Exp Res. 2010 Feb;22(1):20-3. doi: 10.1007/BF03324810.
BACKGROUND AND AIMS
D-dimer is a marker of active fibrinolysis. Understanding how age-related factors affect D-dimer levels may help the interpretation of high D-dimer levels in older individuals.
METHODS
776 Baltimore Longitudinal Study on Aging (BLSA) participants (mean age 68.4+/-13.9 yrs) were divided into three groups according to baseline D-dimer levels >200 ng/mL; 100-200 ng/mL and <100 ng/mL.
RESULTS
D-dimer level increased with age (p<0.0001). Using polychotomous logistic regression models, we found that age, cholesterol, triglycerides, creatinine, erythrocyte sedimentation rate, hemoglobin and body mass index were independently associated with D-dimer level.
CONCLUSIONS
Rising levels of D-dimer with age can be explained in part by the high prevalence of pro-inflammatory conditions and increasing burden of lipid abnormalities, anemia and obesity. These factors compromise the specificity of D-dimer levels as a diagnostic aid to thrombosis in older individuals.
背景与目的
D-二聚体是纤维蛋白溶解活性的标志物。了解与年龄相关的因素如何影响 D-二聚体水平，可能有助于解释老年人中 D-二聚体水平升高的原因。
方法
776 名巴尔的摩纵向衰老研究（BLSA）参与者（平均年龄 68.4±13.9 岁）根据基线 D-二聚体水平>200ng/mL、100-200ng/mL 和<100ng/mL 分为三组。
结果
D-二聚体水平随年龄增长而升高（p<0.0001）。使用多项逻辑回归模型，我们发现年龄、胆固醇、甘油三酯、肌酐、红细胞沉降率、血红蛋白和体重指数与 D-二聚体水平独立相关。
结论
D-二聚体随年龄升高的原因部分可以用炎症状态的高发和脂质异常、贫血和肥胖负担的增加来解释。这些因素降低了 D-二聚体水平作为老年人群血栓形成诊断辅助手段的特异性。
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