金银花提取物对二甲基亚硝胺诱导的大鼠急性肝损伤的保护作用。
Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats.
机构信息
Department of Chemistry and Pharmacy, Jiamusi University, Jiamusi 154007, Heilongjiang, China.
出版信息
J Nat Med. 2010 Jul;64(3):288-94. doi: 10.1007/s11418-010-0405-x. Epub 2010 Mar 20.
The aim of this study is to investigate effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg dimethylnitrosamine (DMN). Model rats were divided into hepatic injury control group (administrated with water), FLE group (administrated with FLE) and silymarin group (administrated with silymarin which is hepatotherapeutic drug) as positive control. They were examined including ALT, AST, ALP, gamma-GT, ALB and TP levels in serum, and MDA, GPx levels in liver tissue. In addition, pathologic changes, particularly fibrosis, were examined by Azan staining. The results revealed that the ALT, AST, ALP, gamma-GT, MDA GPx and liver fibrosis degree in the LJE group were lower than the silymarin group and control group, ALB and TP were higher than the silymarin group and control group. These results suggested that LJE may help in inhibiting of acute liver injury greater than silymarin.
本研究旨在探讨金银花提取物（FLE）对 35mg/kg 二甲基亚硝胺（DMN）诱导的急性肝损伤模型大鼠的作用。模型大鼠分为肝损伤对照组（给予水）、FLE 组（给予 FLE）和水飞蓟素组（给予水飞蓟素，一种肝治疗药物）作为阳性对照。检测血清中 ALT、AST、ALP、γ-GT、ALB 和 TP 水平，肝组织中 MDA、GPx 水平，并通过azan 染色检查病理变化，特别是纤维化。结果表明，与水飞蓟素组和对照组相比，LJE 组的 ALT、AST、ALP、γ-GT、MDA、GPx 和肝纤维化程度较低，ALB 和 TP 较高。这些结果表明，LJE 可能有助于抑制急性肝损伤，其效果优于水飞蓟素。
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