Abdel Samad M M, Guirgis F K, Zeitoun R, El-Feki R F, Awadalla H N
Tropenmed Parasitol. 1977 Dec;28(4):554-9.
MAO activity in liver homogenate of mice infected with Schistosoma mansoni was determined from the second till the 14th week following infection. Significant diminution of MAO activity was noticed starting from the sixth week following infection, reaching its lowest value at the eighth week, obviously denoting progress of hepatic fibrosis. Treatment of the infected, animals with four different antischistosomal agents, tarter emetic, stibophen, niridazole and hycanthone, resulted in an improvement of the enzyme level to an almost normal value. This may indicate the ease with which the lesions in the liver including fibrosis recover when the infection is successfully treated.
测定感染曼氏血吸虫的小鼠肝脏匀浆中从感染后第2周到第14周的单胺氧化酶（MAO）活性。从感染后第6周开始，观察到MAO活性显著降低，在第8周达到最低值，这明显表明肝纤维化在进展。用四种不同的抗血吸虫药（吐酒石、羟锑波芬、硝唑咪和羟氨喹）治疗受感染动物，可使酶水平提高到几乎正常的值。这可能表明当感染得到成功治疗时，包括纤维化在内的肝脏病变恢复得很容易。
