Academic Medical Center, Department Obstetrics and Gynecology, Amsterdam, The Netherlands.
Prenat Diagn. 2010 May;30(5):425-33. doi: 10.1002/pd.2486.
To assess the impact of rapid aneuploidy detection (RAD) combined with fetal karyotyping versus karyotyping only on maternal anxiety and health-related quality of life.
Women choosing to undergo amniocentesis were selected into group 1, i.e. receiving a karyotype result only (n = 132) or to group 2, i.e. receiving both the result of RAD and karyotyping (n = 181).
There were no systematic differences in time of RAD combined with karyotyping versus karyotyping only in terms of anxiety (P = 0.91), generic physical health (P = 0.76, P = 0.46), generic mental health (P = 0.52, P = 0.72), personal perceived control (P = 0.91) and stress (P = 0.13). RAD combined with karyotyping reduced anxiety and stress two weeks earlier compared to karyotyping only.
RAD as add-on to karyotyping reduces anxiety and stress in the short term but it does not influence overall anxiety, stress, personal perceived control, and generic mental and physical health when compared to a karyotype-only strategy.
评估快速染色体非整倍体检测（RAD）联合胎儿核型分析与仅核型分析对产妇焦虑和健康相关生活质量的影响。
选择行羊膜穿刺术的孕妇被纳入第 1 组，即仅接受核型分析结果（n=132）或第 2 组，即同时接受 RAD 和核型分析结果（n=181）。
在焦虑（P=0.91）、一般生理健康（P=0.76，P=0.46）、一般心理健康（P=0.52，P=0.72）、个人感知控制（P=0.91）和压力（P=0.13）方面，RAD 联合核型分析与仅核型分析的时间无系统差异。与仅核型分析相比，RAD 联合核型分析可提前两周降低焦虑和压力。
与仅核型分析相比，RAD 作为核型分析的附加手段可在短期内降低焦虑和压力，但与仅核型分析策略相比，不会影响整体焦虑、压力、个人感知控制以及一般心理和生理健康。
