Chan Yiu Man, Sahota Daljit Singh, Leung Tak Yeung, Choy Kwong Wai, Chan Oi Ka, Lau Tze Kin
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Prenat Diagn. 2009 Dec;29(13):1270-6. doi: 10.1002/pd.2394.
To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state.
Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost.
Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was pound267.82 (95% CI 226.71-323.31). Women would only accept the rapid aneuploidy test if results where available 18 days sooner than if they were undergoing a karyotyping test. Among women who traded between diagnostic tests, the value of extra chromosomal information was reduced to pound153.83 (95% CI 125.81-192.19). Women with high trait anxiety scores (>40) did not preferentially select one test.
Chinese women showed a strong preference towards performing a full karyotype test and having a full chromosomal assessment performed for their pregnancy.
评估中国女性对产前诊断检测方法（核型分析或快速非整倍体检测）的偏好及其与母亲心理状态的关系。
300名同意参与的女性完成了一份自我管理的结构化问卷，该问卷使用离散选择实验设计记录了她们的心理状态以及对染色体异常诊断检测的首选方法。诊断检测根据三个属性进行分类：染色体信息的完整性、从检测到出结果的时间间隔和成本。
无论成本和从检测到出结果的时间间隔如何，参与者都表示更倾向于核型检测。获得核型分析提供的额外信息相对于快速非整倍体检测的价值为267.82英镑（95%可信区间226.71 - 323.31）。只有当快速非整倍体检测结果比核型检测结果早18天出来时，女性才会接受该检测。在对两种诊断检测进行权衡的女性中，额外染色体信息的价值降至153.83英镑（95%可信区间125.81 - 192.19）。特质焦虑得分高（>40）的女性没有优先选择某一种检测方法。
中国女性对进行全面的核型检测以及对其妊娠进行全面的染色体评估表现出强烈的偏好。
