Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands.
Prenat Diagn. 2010 Oct;30(10):928-36. doi: 10.1002/pd.2585.
To assess the reasons and perceptions of women who are offered a choice between karyotyping and standalone rapid aneuploidy detection (RAD) and to compare the impact of both tests on anxiety and health-related quality of life.
In this prospective comparative study, women undergoing amniocentesis on behalf of their age or for an increased Down syndrome risk were offered a choice between karyotyping (group 1, n = 68) and standalone RAD (group 2, n = 61). Follow-up was 9 weeks post amniocentesis.
The most commonly cited reason for choosing karyotyping was obtaining as much information as possible, while for choosing standalone RAD, it was the short waiting time. Prenatal screening (OR 7.09), no knowledge of karyotyping (OR 4.2), and an intermediate perceived risk for chromosomal abnormalities (OR 3.6) were associated with choosing standalone RAD. There were no systematic differences in time of karyotyping and standalone RAD in terms of anxiety (P = 0.11), generic physical and mental health (P = 0.94, 0.52; P = 0.66, 0.07), personal perceived control (PPC; P = 0.69), and stress (P = 0.66).
Offering a choice between karyotyping and standalone RAD does not influence anxiety, stress, PPC, or generic health. Individual choice in prenatal diagnosis meets individual needs and thereby could reduce anxiety and stress.
评估提供核型分析和独立快速非整倍体检测（RAD）选择的女性的原因和看法，并比较两种检测方法对焦虑和健康相关生活质量的影响。
在这项前瞻性比较研究中，对因年龄或唐氏综合征风险增加而接受羊膜穿刺术的女性提供核型分析（第 1 组，n = 68）和独立 RAD 选择（第 2 组，n = 61）。随访时间为羊膜穿刺术后 9 周。
选择核型分析的最常见原因是尽可能获得更多信息，而选择独立 RAD 的原因是等待时间短。产前筛查（OR 7.09）、不了解核型分析（OR 4.2）和中间感知的染色体异常风险（OR 3.6）与选择独立 RAD 相关。在焦虑（P = 0.11）、一般身体和心理健康（P = 0.94，0.52；P = 0.66，0.07）、个人感知控制（PPC；P = 0.69）和压力（P = 0.66）方面，核型分析和独立 RAD 的时间没有系统差异。
提供核型分析和独立 RAD 选择不会影响焦虑、压力、PPC 或一般健康。产前诊断中的个体选择满足了个体需求，从而可以减轻焦虑和压力。
