Department of Toxicology, Faculty of Basic Medicine Science, Second Military Medical University, Shanghai, China.
Drug Chem Toxicol. 2010 Apr;33(2):220-6. doi: 10.3109/01480540903373654.
It is reported that salidroside, the main component of a traditional Chinese medicine, Rhodiola rosea, has the efficacy of protecting Coxsackie virus impairment. As part of a safety evaluation on salidroside for use in the treatment of viral myocarditis, the present study evaluated potential genotoxicity of salidroside by using the standard battery of tests (i.e., bacterial reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay) recommended by the State Food and Drug Administration of China. The results showed that salidroside was not genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay conditions. The anticipated clinical dose seems to be smaller than the doses administered in the genotoxicity assays. With confirmation from further toxicity studies, salidroside would hopefully prove to be a safe anti-Coxsackie virus agent.
据报道，红景天中主要成分红景天苷具有保护柯萨奇病毒损伤的功效。作为红景天苷用于治疗病毒性心肌炎的安全性评价的一部分，本研究采用国家食品药品监督管理局推荐的标准组合试验（即细菌回复突变试验、染色体畸变试验和小鼠微核试验）来评估红景天苷的潜在遗传毒性。结果表明，红景天苷在回复突变试验、染色体畸变试验和小鼠微核试验条件下均无遗传毒性。预期的临床剂量似乎小于遗传毒性试验中给予的剂量。进一步的毒性研究证实后，红景天苷有望成为一种安全的抗柯萨奇病毒药物。
