Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, 94720, USA.
Curr Opin Neurobiol. 2010 Jun;20(3):340-6. doi: 10.1016/j.conb.2010.02.012. Epub 2010 Mar 20.
Although sensory processing in V1 has been extensively characterized, the role of GABAergic inhibition is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of inhibitory processes in vivo. Recent studies have provided important insights into the influence of GABAergic inhibition on cortical processing at both the single cell level, where inhibition helps to shape cortical receptive fields, and at the network level, where inhibition is critical for generating cortical oscillations and setting network state.
尽管 V1 中的感觉处理已经得到了广泛的描述,但 GABA 能抑制的作用仍未得到很好的理解。分子生物学的进步现在已经消除了直接研究体内抑制过程的重大障碍。最近的研究提供了重要的见解,了解 GABA 能抑制对单个细胞水平的皮层处理的影响,其中抑制有助于塑造皮层感受野,以及对网络水平的影响,其中抑制对于产生皮层振荡和设定网络状态至关重要。