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[脊柱关节炎与生活质量]

[Spondyloarthritis and quality of life].

作者信息

Hermann J

机构信息

Klinische Abteilung für Rheumatologie und Immunologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 15, 8036 Graz, Osterreich.

出版信息

Z Rheumatol. 2010 May;69(3):213-9. doi: 10.1007/s00393-009-0572-x.

DOI:10.1007/s00393-009-0572-x
PMID:20309701
Abstract

To measure the disease activity of spondyloarthritides (SpA), quality of life is assessed in addition to inflammation and functional impairment. To measure quality of life in ankylosing spondylitis (AS), the generic measurement instruments SF-36, SF-12 and EQ-5D are available in German, whereby the SF-36 is the instrument primarily used in clinical investigations. Compared to the normal population, AS patients experience a reduced quality of life. In woman and patients with a poor educational background, quality of life was particularly reduced.Measuring quality of life is also a generally recognised part of evaluating psoriasis arthritis (PsA), for which only SF-36 and EQ-5D are available in German-speaking countries. The instrument most frequently used in clinical studies is SF-36. The quality of life in PsA patients, in terms of both physical and mental components, was found to be significantly lower than in the normal population. Although PsA patients shared a similar reduction in quality of life to AS patients, they nevertheless enjoyed a better quality of life than rheumatoid arthritis patients.

摘要

为了衡量脊柱关节炎(SpA)的疾病活动度,除了评估炎症和功能损害外,还会对生活质量进行评估。为了测量强直性脊柱炎(AS)患者的生活质量,通用测量工具SF - 36、SF - 12和EQ - 5D有德语版本,其中SF - 36是临床研究中主要使用的工具。与正常人群相比,AS患者的生活质量有所下降。在女性和教育背景较差的患者中,生活质量下降尤为明显。测量生活质量也是评估银屑病关节炎(PsA)的一个普遍认可的部分,在讲德语的国家只有SF - 36和EQ - 5D这两种工具。临床研究中最常用的工具是SF - 36。发现PsA患者在身体和心理方面的生活质量均显著低于正常人群。尽管PsA患者的生活质量下降程度与AS患者相似,但他们的生活质量仍优于类风湿关节炎患者。

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戈利木单抗,一种新型人肿瘤坏死因子α抗体,每四周皮下注射一次用于治疗银屑病关节炎:一项随机、安慰剂对照研究的24周疗效和安全性结果。
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