Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dicle University School of Medicine, Diyarbakır, Turkey.
Rheumatol Int. 2013 Apr;33(4):1039-45. doi: 10.1007/s00296-012-2513-2. Epub 2012 Sep 2.
The aim of this study is to investigate sleep quality in patients with ankylosing spondylitis (AS) and to evaluate the relationship of the disease parameters with sleep disturbance. Eighty AS patients (60 males and 20 females) fulfilling the modified New York criteria, and 52 age- and gender-matched controls (33 males and 19 females) were enrolled in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Pain was measured by visual analogue scale. The disease activity and functional status were assessed by the Bath AS disease Activity Index and the Bath AS Functional Index. The Bath AS Metrology Index was used to evaluate mobility restrictions, and the Bath AS Radiology Index was employed to evaluate the radiological damage. The psychological status and quality of life were assessed with the hospital anxiety-depression scale and AS quality of life scale. The patients with AS had significantly more unfavourable scores in the subjective sleep quality, habitual sleep efficiency domains (p < 0.001) and the total PSQI score (p < 0.05). Poor sleep quality (total PSQI score) was positively correlated with increased pain, poor quality of life, higher depressed mood, higher disease activity and mobility restrictions. Pain was also an independent contributor to poorer sleep quality (p = 0.002). The sleep quality is disturbed in patients with AS. The lower quality of sleep is greatly associated with the pain, disease activity, depression, quality of life and increased limitation of mobility.
本研究旨在探讨强直性脊柱炎（AS）患者的睡眠质量，并评估疾病参数与睡眠障碍的关系。 研究纳入了 80 名符合改良纽约标准的 AS 患者（60 名男性和 20 名女性）和 52 名年龄和性别匹配的对照组（33 名男性和 19 名女性）。 睡眠质量采用匹兹堡睡眠质量指数（PSQI）进行评估。 疼痛采用视觉模拟量表进行测量。 疾病活动度和功能状态采用 Bath AS 疾病活动指数和 Bath AS 功能指数进行评估。 Bath AS 计量学指数用于评估运动受限，Bath AS 放射学指数用于评估放射学损伤。 心理状态和生活质量采用医院焦虑抑郁量表和 AS 生活质量量表进行评估。 AS 患者在主观睡眠质量、习惯性睡眠效率领域（p<0.001）和 PSQI 总分（p<0.05）的评分明显较差。 睡眠质量差（PSQI 总分）与疼痛增加、生活质量差、抑郁情绪加重、疾病活动度增加和运动受限有关。 疼痛也是导致睡眠质量较差的独立因素（p=0.002）。 AS 患者的睡眠质量受到干扰。 睡眠质量较差与疼痛、疾病活动度、抑郁、生活质量和运动受限增加密切相关。
