• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association.

作者信息

Andreetto Erika, Yan Li-Mei, Tatarek-Nossol Marianna, Velkova Aleksandra, Frank Ronald, Kapurniotu Aphrodite

机构信息

Laboratory of Peptide Biochemistry, Center of Integrated Protein Science, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising-Weihenstephan, Germany.

出版信息

Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3081-5. doi: 10.1002/anie.200904902.

DOI:10.1002/anie.200904902
PMID:20309983
Abstract
摘要

相似文献

1
Identification of hot regions of the Abeta-IAPP interaction interface as high-affinity binding sites in both cross- and self-association.鉴定淀粉样β蛋白-胰岛淀粉样多肽相互作用界面的热点区域作为交叉关联和自关联中的高亲和力结合位点。
Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3081-5. doi: 10.1002/anie.200904902.
2
IAPP mimic blocks Abeta cytotoxic self-assembly: cross-suppression of amyloid toxicity of Abeta and IAPP suggests a molecular link between Alzheimer's disease and type II diabetes.胰岛淀粉样多肽类似物可阻断β淀粉样蛋白的细胞毒性自组装：β淀粉样蛋白与胰岛淀粉样多肽的淀粉样毒性相互抑制，提示阿尔茨海默病与II型糖尿病之间存在分子联系。
Angew Chem Int Ed Engl. 2007;46(8):1246-52. doi: 10.1002/anie.200604056.
3
Controlling amyloid growth in multiple dimensions.多维度控制淀粉样蛋白生长
Amyloid. 2006 Dec;13(4):206-15. doi: 10.1080/13506120600960809.
4
Humoral immune response to fibrillar beta-amyloid peptide.对纤维状β-淀粉样肽的体液免疫反应。
Biochemistry. 2003 Oct 14;42(40):11682-92. doi: 10.1021/bi030100s.
5
Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease.人类和啮齿动物的β-淀粉样肽与血红素的结合存在差异：与人类患阿尔茨海默病的易感性相关。
Arch Biochem Biophys. 2009 Jul 1;487(1):59-65. doi: 10.1016/j.abb.2009.05.003. Epub 2009 May 18.
6
A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis.一种抑制淀粉样β蛋白寡聚化和纤维形成的肽发夹抑制剂。
Biochemistry. 2009 Dec 8;48(48):11329-31. doi: 10.1021/bi901325g.
7
Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.解析淀粉样肽模拟物和淀粉样肽中单一区域在抑制 Aβ40 淀粉样纤维形成和细胞毒性方面的作用。
Chembiochem. 2011 Jun 14;12(9):1313-22. doi: 10.1002/cbic.201100192. Epub 2011 May 31.
8
Two-site binding of beta-cyclodextrin to the Alzheimer Abeta(1-40) peptide measured with combined PFG-NMR diffusion and induced chemical shifts.结合脉冲场梯度核磁共振扩散法和诱导化学位移法测定β-环糊精与阿尔茨海默病β淀粉样蛋白（1-40）肽的双位点结合
Biochemistry. 2004 May 25;43(20):6261-9. doi: 10.1021/bi036254p.
9
Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta1-42 by mirror image phage display.通过镜像噬菌体展示筛选与阿尔茨海默病淀粉样肽β1-42结合的D-氨基酸肽。
Chembiochem. 2003 Aug 4;4(8):748-53. doi: 10.1002/cbic.200300631.
10
NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid beta.NMR 研究溶菌 GM1 胶束与淀粉样β之间的相互作用
FEBS Lett. 2010 Feb 19;584(4):831-6. doi: 10.1016/j.febslet.2010.01.005. Epub 2010 Jan 12.

引用本文的文献

1
Human amylin is a potent antimicrobial peptide that exhibits antimicrobial synergism with the amyloid beta protein.人胰岛淀粉样多肽是一种有效的抗菌肽，与β-淀粉样蛋白具有抗菌协同作用。
Alzheimers Dement. 2025 Aug;21(8):e70490. doi: 10.1002/alz.70490.
2
Bridging Pancreatic Amyloidosis and Neurodegeneration: The Emerging Role of Amylin in Diabetic Dementia.连接胰腺淀粉样变性与神经退行性变：胰岛淀粉样多肽在糖尿病性痴呆中的新作用
Int J Mol Sci. 2025 May 23;26(11):5021. doi: 10.3390/ijms26115021.
3
Determinants for Substoichiometric Inhibition of IAPP and Aβ Amyloid Aggregations by Bri2 BRICHOS.
Bri2 BRICHOS对胰岛淀粉样多肽（IAPP）和β淀粉样蛋白（Aβ）淀粉样聚集的亚化学计量抑制的决定因素
ACS Chem Neurosci. 2025 Mar 19;16(6):1150-1160. doi: 10.1021/acschemneuro.4c00839. Epub 2025 Mar 4.
4
Detection of Amylin-β-amyloid Hetero-Oligomers by Enzyme-Linked Immunosorbent Assay.通过酶联免疫吸附测定法检测胰淀素-β-淀粉样蛋白异源寡聚体
Bio Protoc. 2025 Feb 5;15(3):e5179. doi: 10.21769/BioProtoc.5179.
5
Heterotypic Interactions of Amyloid β and the Islet Amyloid Polypeptide Produce Mixed Aggregates with Non-Native Fibril Structure.淀粉样β蛋白与胰岛淀粉样多肽的异型相互作用产生具有非天然纤维结构的混合聚集体。
J Phys Chem Lett. 2024 Dec 12;15(49):12197-12205. doi: 10.1021/acs.jpclett.4c02827. Epub 2024 Dec 3.
6
Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide.计算洞察主动脉淀粉样 medin 多肽的聚集机制和淀粉样形成核心。
Colloids Surf B Biointerfaces. 2024 Dec;244:114192. doi: 10.1016/j.colsurfb.2024.114192. Epub 2024 Aug 30.
7
Islet amyloid polypeptide fibril catalyzes amyloid-β aggregation by promoting fibril nucleation rather than direct axial growth.胰岛淀粉样多肽纤维能通过促进纤维成核而非直接轴向生长来催化淀粉样-β聚合。
Int J Biol Macromol. 2024 Nov;279(Pt 1):135137. doi: 10.1016/j.ijbiomac.2024.135137. Epub 2024 Aug 27.
8
Inhibition of the Early-Stage Cross-Amyloid Aggregation of Amyloid-β and IAPP via EGCG: Insights from Molecular Dynamics Simulations.表没食子儿茶素没食子酸酯对β-淀粉样蛋白和胰岛淀粉样多肽早期交叉淀粉样聚集的抑制作用：来自分子动力学模拟的见解
ACS Omega. 2024 Jul 3;9(28):30256-30269. doi: 10.1021/acsomega.4c00500. eCollection 2024 Jul 16.
9
Changes in hippocampal volume, synaptic plasticity and amylin sensitivity in an animal model of type 2 diabetes are associated with increased vulnerability to amyloid-beta in advancing age.2型糖尿病动物模型中海马体积、突触可塑性和胰淀素敏感性的变化与老年时对β-淀粉样蛋白的易感性增加有关。
Front Aging Neurosci. 2024 Jun 21;16:1373477. doi: 10.3389/fnagi.2024.1373477. eCollection 2024.
10
Computational Investigation of Coaggregation and Cross-Seeding between Aβ and hIAPP Underpinning the Cross-Talk in Alzheimer's Disease and Type 2 Diabetes.计算研究阿尔茨海默病和 2 型糖尿病中淀粉样蛋白-β（Aβ）和人胰岛淀粉样多肽（hIAPP）的共聚集和交叉成核，为它们之间的串扰提供依据。
J Chem Inf Model. 2024 Jul 8;64(13):5303-5316. doi: 10.1021/acs.jcim.4c00859. Epub 2024 Jun 26.