Harley J B, Grinspan S, Root R K
Yale J Biol Med. 1977 Sep-Oct;50(5):481-8.
The clinical course of a young woman following two separate suicide attempts using the herbicide paraquat is reported. The patient survived an intramuscular injection of paraquat almost asymptomatically, but later exhibited a typical fatal course with fulminant proliferative pulmonary fibrosis after an intravenous injection. Fibrosis and death occurred despite a therapeutic regimen based upon a known action of paraquat, the generation of superoxide (O(2)[unk]), using superoxide dismutase, α-tocopherol, and ascorbic acid in conjunction with forced diuresis and prednisone. While treatment failed explanations for the failure of therapy in this case and current therapeutic alternatives are discussed so that they may be considered when future cases are encountered.
报告了一名年轻女性两次使用除草剂百草枯自杀未遂后的临床病程。患者肌肉注射百草枯后几乎无症状存活，但后来静脉注射后出现典型的致命病程，伴有暴发性增殖性肺纤维化。尽管采用了基于百草枯已知作用（产生超氧阴离子（O(2)[未知]））的治疗方案，联合使用超氧化物歧化酶、α-生育酚和抗坏血酸并强制利尿及使用泼尼松，但仍发生了纤维化和死亡。本文讨论了该病例治疗失败的原因以及当前的治疗替代方案，以便在未来遇到类似病例时可供参考。
