Tkác I, Moscovic F, Molcányiová A
Clinic of Internal Medicine IV, Faculty of Medicine, University Hospital, Kosice, Czechoslovakia.
Vasa. 1991;20(1):22-5.
The levels of creatinine, urea, uric acid, UPE and blood pressure were measured in the groups of Type 2 diabetics with proximal (iliocofemoral) type (PRMA) and distal (tibial) type of macroangiopathy (DIMA) (diagnosed by means of Doppler ultrasound technique) and in a control group without lower limb macroangiopathy. Both UPE and creatinine mean values were significantly increased in the PRMA group in comparison with controls. Uric acid levels were increased in both PRMA and DIMA groups and mean urea values did not differ significantly in all three groups of patients. Systolic blood pressure values were similar in each group as well. However, a significant increase of mean diastolic pressure has been observed in the group with DIMA. In addition, significant correlation was observed between the thigh/arm index (expressing the perfusion through the ilicofemoral segment) and UPE (r = -0.464; p less than 0.001). This relationship persisted also in multivariate analysis where UPE was the only factor which entered the "best fit model". The results of the present study indicate that proteinuria might be a risk factor or a marker for proximal type of peripheral vascular disease in Type 2 diabetic mellitus.
通过多普勒超声技术诊断，对患有近端（髂股型）大血管病变（PRMA）和远端（胫型）大血管病变（DIMA）的2型糖尿病患者组以及无下肢大血管病变的对照组进行肌酐、尿素、尿酸、尿蛋白排泄率（UPE）和血压水平的测量。与对照组相比，PRMA组的UPE和肌酐平均值均显著升高。PRMA组和DIMA组的尿酸水平均升高，三组患者的尿素平均值无显著差异。每组的收缩压值也相似。然而，观察到DIMA组的平均舒张压显著升高。此外，观察到大腿/手臂指数（表示通过髂股段的灌注情况）与UPE之间存在显著相关性（r = -0.464；p < 0.001）。在多变量分析中，这种关系依然存在，其中UPE是唯一进入“最佳拟合模型”的因素。本研究结果表明，蛋白尿可能是2型糖尿病患者近端型外周血管疾病的一个危险因素或标志物。
