Tkác I, Tkácová R, Takác M, Lazúr J
Department of Internal Medicine IV, University of Kosice, Czech and Slovak Federal Republic.
Vasa. 1992;21(4):360-4.
Some hematologic parameters have been measured in 80 patients with Type 2 diabetes mellitus. The patients were divided into three groups: (a) proximal (pelvic and femoral) lower limb macroangiopathy; (b) distal (tibial) macroangiopathy; and (c) control group of diabetics without lower limb macroangiopathy. Mean hemoglobin, hematocrit and fibrinogen values were significantly higher in both the proximal and distal macroangiopathy groups in comparison with the controls. On the other hand, mean leucocyte and platelet counts were significantly elevated only in the proximal macroangiopathy group. Significant correlations were observed in univariate and multivariate analyses between blood fibrinogen concentration and pressure indices expressing severity of lower limb macroangiopathy (ankle/thigh, ankle/arm). In summary, increased levels of hematologic parameters contributing to the increase of whole blood viscosity were observed in Type 2 diabetics with arteriosclerosis obliterans. The observed relationship between fibrinogen concentration and severity of arteriosclerosis obliterans could be an evidence in favor for fibrinogen lowering therapy in this pathologic condition.
已对80例2型糖尿病患者的一些血液学参数进行了测量。这些患者被分为三组：(a) 近端（骨盆和股骨）下肢大血管病变；(b) 远端（胫骨）大血管病变；以及 (c) 无下肢大血管病变的糖尿病对照组。与对照组相比，近端和远端大血管病变组的平均血红蛋白、血细胞比容和纤维蛋白原值均显著更高。另一方面，仅近端大血管病变组的平均白细胞和血小板计数显著升高。在单变量和多变量分析中，观察到血液纤维蛋白原浓度与表示下肢大血管病变严重程度的压力指数（踝/大腿、踝/臂）之间存在显著相关性。总之，在患有闭塞性动脉硬化的2型糖尿病患者中，观察到有助于全血粘度增加的血液学参数水平升高。观察到的纤维蛋白原浓度与闭塞性动脉硬化严重程度之间的关系可能是支持在这种病理状况下进行降低纤维蛋白原治疗的一个证据。
