Aryal Madhukar, Jha Bharat
Department of Biochemistry, BP. Koirala Institute of Health Science, Dharan, Nepal.
Nepal Med Coll J. 2006 Dec;8(4):250-3.
This is a cross sectional hospital based study carried out at Om Hospital and Research Center Kathmandu, Nepal. In the study, 200 diabetic patients attending the hospital were taken as the subjects and we evaluated the urinary albumin excretion and other biochemical parameters (such as creatinine, total cholesterol, HDL cholesterol, LDL cholesterol), blood pressure and body mass index (BMI). Among these 200 patients with type 2 diabetes mellitus (DM), 52.0% were having high blood pressure. The proteinuria was present in 23.0% of the overall subjects but when it is categorized in hypertensive and non-hypertensive group, 30.7% of the diabetic patients with hypertension were having proteinuria. It has been found that males were having higher prevalence ofproteinuria (53.8%) than female (17.6%). There was significant difference in systolic blood pressure, diastolic blood pressure in nephropathy and without nephropathy group. Thus the nephropathy or the incidence of proteinuria was associated with obesity, high diastolic blood pressure and male sex. These data suggest that control of diabetes; hypertension should decrease the risk for proteinuria thus decreasing end stage renal disease (ESRD) and mortality from ESRD.
这是一项在尼泊尔加德满都奥姆医院及研究中心开展的基于医院的横断面研究。在该研究中，选取了200名到该院就诊的糖尿病患者作为研究对象，我们评估了尿白蛋白排泄量以及其他生化指标（如肌酐、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）、血压和体重指数（BMI）。在这200名2型糖尿病（DM）患者中，52.0%患有高血压。蛋白尿在所有研究对象中的占比为23.0%，但在分为高血压组和非高血压组后，30.7%的糖尿病高血压患者存在蛋白尿。研究发现，男性蛋白尿患病率（53.8%）高于女性（17.6%）。肾病组和无肾病组的收缩压、舒张压存在显著差异。因此，肾病或蛋白尿的发生率与肥胖、高舒张压及男性性别有关。这些数据表明，控制糖尿病和高血压应能降低蛋白尿风险，从而降低终末期肾病（ESRD）的风险以及ESRD导致的死亡率。
