Samuelsson L, Jönsson L, Lamm I L, Lindén C J, Ewers S B
Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Acta Radiol. 1991 Mar;32(2):178-81.
In order to make electrolytic tumor destruction more effective new electrode materials were tested (Part I) as well as a combination of electrolysis and megavolt therapy (Part II). All tests were performed in experimental tumors implanted subcutaneously in rats. Altogether in 41 rats in 5 series (Part I) electrodes made of rhodium (Rh), copper (Cu), or brass (Zn-Cu alloy) were investigated but the effect was not found to be better than that of the previously tested platinum (Pt). Oxidation and corrosion made Rh and Cu electrodes less suitable for electrolysis compared to Pt, while brass electrodes became isolated through zinc-salt-formation and performed unsatisfactorily. The radiosensitizing properties of electrolysis were tested in 55 rats with experimental tumors (Part II). One control group had only Co-irradiation, while in 2 other groups Cu- or Pt-electrolysis of the tumors was carried out before irradiation. The combined treatment resulted in a significantly better effect on the tumors, registered as inhibition of tumor growth or disappearance of tumor. As the electrolyzed, necrotic tissue remained in the tumor the effect might not be mediated through diminished target volume. An inflammatory reaction around the electrolytic lesion with increased blood flow and higher oxygenation of the tumor could cause a more positive response to megavolt treatment.
为提高电解肿瘤消融的效果，对新型电极材料（第一部分）以及电解与兆伏级治疗相结合的方法（第二部分）进行了测试。所有测试均在大鼠皮下植入的实验性肿瘤中进行。在5个系列的41只大鼠中（第一部分），研究了由铑（Rh）、铜（Cu）或黄铜（锌 - 铜合金）制成的电极，但发现其效果并不比先前测试的铂（Pt）更好。与铂相比，氧化和腐蚀使铑和铜电极不太适合用于电解，而黄铜电极因形成锌盐而绝缘，性能不佳。在55只患有实验性肿瘤的大鼠中测试了电解的放射增敏特性（第二部分）。一个对照组仅接受钴照射，而在另外两个组中，在照射前对肿瘤进行铜或铂电解。联合治疗对肿瘤产生了明显更好的效果，表现为肿瘤生长受到抑制或肿瘤消失。由于电解后的坏死组织留在肿瘤中，这种效果可能不是通过减小靶体积来介导的。电解损伤周围的炎症反应，伴随着肿瘤血流量增加和氧合作用增强，可能会对兆伏级治疗产生更积极的反应。
