丙酰-L-肉碱对离体兔心机械功能的影响。

Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart.

作者信息

Ferrari R, Pasini E, Condorelli E, Boraso A, Lisciani R, Marzo A, Visiou O

机构信息

Cattedra di Cardiologia, Universita degli Studi di Brescia, Italy.

出版信息

Cardiovasc Drugs Ther. 1991 Feb;5 Suppl 1:17-23. doi: 10.1007/BF00128239.

DOI:10.1007/BF00128239

PMID:2031870

Abstract

We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnitine had no effect on inotropism, heart rate, or coronary perfusion pressure. When added chronically, propionyl-L-carnitine induced a positive inotropic effect, with no changes in heart rate or in coronary perfusion pressure, and it ameliorated the pressure-volume relationship. This effect of propionyl-L-carnitine was independent of the calcium concentration of the perfusion medium, but it was correlated with an increase in the myocardial content of propionyl-L-carnitine. The effect was not apparent after 5 days of treatment, although the tissue content of propionyl-L-carnitine remained unchanged. These data suggest that propionyl-L-carnitine, when given chronically, exerts a positive inotropic effect.

摘要

我们研究了丙酰-L-肉碱（PLC）对离体兔心机械功能的急性和慢性影响。将丙酰-L-肉碱直接加入灌注液（10⁻⁹至10⁻³M）中，或对动物腹腔注射（250mg/kg），持续10天。急性添加时，丙酰-L-肉碱对心肌收缩力、心率或冠状动脉灌注压无影响。慢性添加时，丙酰-L-肉碱可诱导正性肌力作用，心率和冠状动脉灌注压无变化，并改善压力-容积关系。丙酰-L-肉碱的这种作用与灌注液中的钙浓度无关，但与心肌中丙酰-L-肉碱含量的增加相关。治疗5天后该作用不明显，尽管组织中丙酰-L-肉碱含量保持不变。这些数据表明，长期给予丙酰-L-肉碱可发挥正性肌力作用。