丙酰-L-肉碱对链脲佐菌素诱导的糖尿病大鼠心脏功能障碍的影响。

Effects of propionyl-L-carnitine on cardiac dysfunction in streptozotocin-diabetic rats.

作者信息

Terada R, Matsubara T, Koh N, Nakamura J, Hotta N

机构信息

Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Eur J Pharmacol. 1998 Sep 18;357(2-3):185-91. doi: 10.1016/s0014-2999(98)00539-1.

DOI:10.1016/s0014-2999(98)00539-1

PMID:9797035

Abstract

The effects of orally administered propionyl-L-carnitine on cardiac dysfunction in rats with streptozotocin-induced diabetes were investigated. Wistar male rats were divided into four groups: untreated normal, propionyl-L-carnitine (daily for 4 weeks with 3 g/kg orally) -treated normal, untreated diabetic, propionyl-L-carnitine-treated diabetic. Four weeks after streptozotocin administration, plasma lipid levels were increased and myocardial carnitine content was decreased in untreated diabetic rats. These changes were significantly reversed by the propionyl-L-carnitine treatment. Assessment of cardiac function with isolated perfused working hearts revealed a depression of left ventricular developed pressure as well as both maximum positive and negative dP/dt in untreated diabetic as compared with that in normal hearts. Cardiac function at the higher left atrial filling pressures in the propionyl-L-carnitine-treated diabetic rats was improved significantly compared to that in untreated hearts. The data thus suggest that oral administration of propionyl-L-carnitine can reduce abnormalities of cardiac function, correlated with a significant increase in myocardial carnitine content and improved lipid metabolism in terms of lowered plasma lipids.

摘要

研究了口服丙酰-L-肉碱对链脲佐菌素诱导的糖尿病大鼠心脏功能障碍的影响。将雄性Wistar大鼠分为四组：未治疗的正常组、丙酰-L-肉碱（每日口服3 g/kg，共4周）治疗的正常组、未治疗的糖尿病组、丙酰-L-肉碱治疗的糖尿病组。给予链脲佐菌素4周后，未治疗的糖尿病大鼠血浆脂质水平升高，心肌肉碱含量降低。丙酰-L-肉碱治疗可显著逆转这些变化。通过离体灌注工作心脏评估心脏功能发现，与正常心脏相比，未治疗的糖尿病心脏左心室舒张末压以及最大正负dP/dt均降低。与未治疗的心脏相比，丙酰-L-肉碱治疗的糖尿病大鼠在较高左心房充盈压下的心脏功能显著改善。因此，数据表明口服丙酰-L-肉碱可减少心脏功能异常，这与心肌肉碱含量显著增加以及血浆脂质降低所改善的脂质代谢相关。