Leasure J E, Kordenat K
Cox Heart Institute, Wright State University, School of Medicine, Dayton, OH 45429.
Cardiovasc Drugs Ther. 1991 Feb;5 Suppl 1:85-95. doi: 10.1007/BF00128247.
Limitation on infarct size, using propionyl-L-carnitine (Sigma-Tau) by itself and with the calcium entry blocker, tiapamil (Hoffmann-LaRoche), was evaluated in two groups of ten dogs each, during chronic (9 days) myocardial infarction. There were eight dogs that served as the control group. A closed-chest model was used to produce the thrombus by placing a helically shaped copper wire in the LAD by catheter technique, under x-ray visualization. Necrotic tissue in serial transventricular sections were delineated by triphenyltetrazolium chloride and measured by computer technique, using an IBM PC interfaced with a digitizing pad, 9 days following occlusion. The mean total amount of necrosis in the propionyl-L-carnitine (7.4%) and the propionyl-L-carnitine/tiapamil (6.7%) groups were significantly less (p less than .01) than found in the control (14.1%) group, reflecting a difference of 50 and 58%, respectively, between the treated groups and control. A number of significant between-group comparisons (p less than .05 to p less than .001), under the same conditions, were found for various ischemia, hemodynamic, and hematologic variables followed before and at 30, 60, 90, 120, and 180 minutes after occlusion, as well as on the second and ninth day. The results of this study strongly suggest that propionyl-L-carnitine and propionyl-L-carnitine with tiapamil has a protective effect on myocardial function, following thrombotic occlusion of the LAD, as well as limiting the resulting infarct size.
在两组各十只犬的慢性（9天）心肌梗死期间，评估单独使用丙酰-L-肉碱（西格玛-陶公司）以及联合钙通道阻滞剂替帕米（霍夫曼-罗氏公司）对梗死面积的限制作用。有八只犬作为对照组。采用闭胸模型，通过导管技术在X线透视下将螺旋形铜丝置于左前降支以形成血栓。在闭塞9天后，用氯化三苯基四氮唑勾勒连续心室切片中的坏死组织，并使用与数字化板连接的IBM个人计算机通过计算机技术进行测量。丙酰-L-肉碱组（7.4%）和丙酰-L-肉碱/替帕米组（6.7%）的平均坏死总量显著低于对照组（14.1%）（p<0.01），这表明治疗组与对照组之间的差异分别为50%和58%。在相同条件下，对闭塞前以及闭塞后30、60、90、120和180分钟以及第二天和第九天的各种缺血、血流动力学和血液学变量进行了多项组间显著比较（p<0.05至p<0.001）。本研究结果强烈表明，丙酰-L-肉碱以及丙酰-L-肉碱与替帕米联合使用对左前降支血栓闭塞后的心肌功能具有保护作用，并能限制由此产生的梗死面积。
