Bonney R C, Higham J M, Watson H, Beesley J S, Shaw R W, Franks S
Unit of Metabolic Medicine, St. Mary's Hospital Medical School, London.
Br J Obstet Gynaecol. 1991 Apr;98(4):363-8. doi: 10.1111/j.1471-0528.1991.tb13426.x.
The activity of phospholipase A2 types 1 and 2 and phospholipase C was measured in the endometrium of women with ovulatory menorrhagia and in those with normal menstrual blood loss. In both groups of subjects phospholipase A2 type 1 activity was significantly higher in the secretory phase than in the proliferative phase (P less than 0.001). The median activity (pmol/mg protein/min) for the proliferative phase was 27.6 in normal subjects and 40.4 in women with ovulatory menorrhagia and for the secretory phase the median activity was 144.5 in normal women and 138.1 in women with ovulatory menorrhagia. There was no difference between the two groups of women at either stage of the cycle. Phospholipase A2 type 2 activity was also higher in the secretory phase than in the proliferative phase (P less than 0.05 for normal subjects and P less than 0.001 for women with menorrhagia). The median activity (pmol/mg protein/min) for the proliferative phase was 94.4 (normal subjects) and 56.6 (women with menorrhagia) and for the secretory phase 148.3 (normal subjects) and 142.5 (women with menorrhagia). The activity of phospholipase A2 type 2 was significantly lower in the proliferative phase of women with ovulatory menorrhagia compared with normal subjects (P less than 0.05). Phospholipase C activity (nmol/mg protein/min) was significantly higher in women with ovulatory menorrhagia (median 8.2) compared with women with normal blood loss (median 5.5) (P less than 0.01).
对排卵型月经过多的女性和月经失血量正常的女性的子宫内膜，进行了1型和2型磷脂酶A2以及磷脂酶C活性的测定。在两组受试者中，1型磷脂酶A2活性在分泌期均显著高于增殖期（P<0.001）。增殖期正常受试者的中位活性（pmol/mg蛋白质/分钟）为27.6，排卵型月经过多的女性为40.4；分泌期正常女性的中位活性为144.5，排卵型月经过多的女性为138.1。在月经周期的任何一个阶段，两组女性之间均无差异。2型磷脂酶A2活性在分泌期也高于增殖期（正常受试者P<0.05，月经过多的女性P<0.001）。增殖期的中位活性（pmol/mg蛋白质/分钟）正常受试者为94.4，月经过多的女性为56.6；分泌期正常受试者为148.3，月经过多的女性为142.5。与正常受试者相比，排卵型月经过多的女性在增殖期2型磷脂酶A2活性显著降低（P<0.05）。与月经失血量正常的女性（中位值5.5）相比，排卵型月经过多的女性的磷脂酶C活性（nmol/mg蛋白质/分钟）显著更高（中位值8.2）（P<0.01）。
