Drake M E, Pakalnis A, Phillips B, Padamadan H, Hietter S A
Clinical Neurophysiology Laboratory, Ohio State University Hospitals, Columbus.
Clin Electroencephalogr. 1991 Apr;22(2):97-101. doi: 10.1177/155005949102200209.
The pathophysiology of anxiety has received much recent attention. EEG findings in anxiety are nonspecific, and some changes in psychophysiological measures have been reported. We recorded short-latency brainstem auditory evoked potentials (BAEPs) and long-latency auditory event-related potentials (AEPs) in 12 patients with generalized anxiety disorder. All 12 patients had BAEP latencies within clinical norms, but I-V interpeak latencies were significantly longer in patients with anxiety than controls. N1, N2, P2, and P3 AEP components were within normal limits; N1 and P2 were reduced in amplitude in anxiety patients, but differences from controls were not significant. The BAEP findings may suggest altered brain-stem function in anxiety, which has been implied by biochemical studies of anxiety and depression. AEP differences may be related to difficulties in concentration and attention direction reported by anxious patients.
焦虑症的病理生理学最近受到了很多关注。焦虑症患者的脑电图结果是非特异性的，并且已经报道了心理生理测量中的一些变化。我们记录了12例广泛性焦虑症患者的短潜伏期脑干听觉诱发电位（BAEP）和长潜伏期听觉事件相关电位（AEP）。所有12例患者的BAEP潜伏期均在临床正常范围内，但焦虑症患者的I-V峰间潜伏期明显长于对照组。N1、N2、P2和P3 AEP成分在正常范围内；焦虑症患者的N1和P2波幅降低，但与对照组的差异不显著。BAEP结果可能提示焦虑症患者脑干功能发生改变，这在焦虑症和抑郁症生化研究中已有暗示。AEP差异可能与焦虑症患者报告的注意力集中和注意力指向困难有关。
