新生大鼠单眼摘除对视神经的影响。

Nicoll A, Bedi K S, Wigmore P M

University of Aberdeen, Department of Anatomy, Marischal College, Scotland.

J Anat. 1991 Feb;174:27-35.

It is known that removal of one eye in the rat in early postnatal life results in an aberrant ipsilateral projection from the remaining eye. We have estimated the number of optic nerve fibres in 36 days old Black and White Hooded rats that had been unilaterally enucleated at birth. There was no significant difference in the transverse cross-sectional area of the optic nerves of control and enucleated rats. Control animals had an average of about 109,000 myelinated fibres and about 11,000 unmyelinated fibres. The mean minimum diameter of the myelinated fibres was 0.73 microns. The corresponding values in the unilaterally enucleated animals were not significantly different from control animals. These results are discussed in the context of the previously reported increased ipsilateral projection in unilaterally enucleated rats.

众所周知，在出生后早期摘除大鼠的一只眼睛会导致另一只眼睛出现异常的同侧投射。我们估计了出生时单侧摘除眼球的36日龄黑白花大鼠视神经纤维的数量。对照大鼠和摘除眼球大鼠的视神经横截面积没有显著差异。对照动物平均约有109,000条有髓纤维和约11,000条无髓纤维。有髓纤维的平均最小直径为0.73微米。单侧摘除眼球动物的相应值与对照动物没有显著差异。将结合之前报道的单侧摘除眼球大鼠同侧投射增加的情况对这些结果进行讨论。