协同唑，一种新型抗真菌抗生素。
Synerazol, a new antifungal antibiotic.
作者信息
Ando O, Satake H, Nakajima M, Sato A, Nakamura T, Kinoshita T, Furuya K, Haneishi T
机构信息
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1991 Apr;44(4):382-9. doi: 10.7164/antibiotics.44.382.
PMID:2032946
Abstract
Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.
摘要
新的抗真菌抗生素西奈唑是从烟曲霉SANK 10588的培养液中分离得到的。其结构是根据核磁共振和质谱证据确定的。西奈唑被发现是伪青霉素A的相关物质。西奈唑对白色念珠菌和其他真菌具有活性，并与唑类抗真菌剂表现出显著的协同活性。
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