• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Synergistic cytotoxicity of human recombinant tumour necrosis factor alpha combined with microtubule effectors.人重组肿瘤坏死因子α与微管效应物联合的协同细胞毒性
J Cancer Res Clin Oncol. 1991;117(3):239-43. doi: 10.1007/BF01625431.
2
Interferon gamma and tumour necrosis factor alpha induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro.干扰素γ和肿瘤坏死因子α在体外对人尤因肉瘤细胞诱导出协同性抗增殖反应。
J Cancer Res Clin Oncol. 1993;119(10):615-21. doi: 10.1007/BF01372725.
3
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
4
Synergistic antitumor effect of a penicillin derivative combined with thapsigargin in melanoma cells.青霉素衍生物与 thapsigargin 联合对黑素瘤细胞的协同抗肿瘤作用。
J Cancer Res Clin Oncol. 2022 Dec;148(12):3361-3373. doi: 10.1007/s00432-022-04129-4. Epub 2022 Jun 25.
5
Influence of recombinant tumour necrosis factor alpha on blood flow and antibody localisation in human tumour xenografts in nude mice.重组肿瘤坏死因子α对裸鼠人肿瘤异种移植模型中血流及抗体定位的影响
J Cancer Res Clin Oncol. 1991;117(6):543-8. doi: 10.1007/BF01613286.
6
First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer.晚期表皮生长因子受体（EGFR）突变阳性非鳞状非小细胞肺癌的一线治疗
Cochrane Database Syst Rev. 2016 May 25(5):CD010383. doi: 10.1002/14651858.CD010383.pub2.
7
Safety of regular formoterol or salmeterol in children with asthma: an overview of Cochrane reviews.福莫特罗或沙美特罗常规用药对哮喘儿童的安全性：Cochrane系统评价综述
Cochrane Database Syst Rev. 2012 Oct 17;10(10):CD010005. doi: 10.1002/14651858.CD010005.pub2.
8
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病：网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
9
Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice.TNP-470与化学免疫疗法联合治疗对小鼠的增强抗肿瘤作用
J Cancer Res Clin Oncol. 2002 Aug;128(8):433-42. doi: 10.1007/s00432-002-0356-z. Epub 2002 Aug 2.
10
Combined programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 blockade in an international cohort of patients with acral lentiginous melanoma.肢端雀斑样痣黑色素瘤国际患者队列中程序性细胞死亡蛋白1与细胞毒性T淋巴细胞相关蛋白4联合阻断治疗
Br J Dermatol. 2025 Jan 24;192(2):316-326. doi: 10.1093/bjd/ljae401.

本文引用的文献

1
Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.肿瘤坏死血清体外细胞毒性机制中内化作用的可能需求。
Cancer Res. 1981 Dec;41(12 Pt 1):4885-90.
2
Cell cycle-specific effects of tumor necrosis factor.肿瘤坏死因子的细胞周期特异性效应
Cancer Res. 1984 Jan;44(1):83-90.
3
Taxol: an antimitotic agent with a new mechanism of action.紫杉醇：一种具有全新作用机制的抗有丝分裂剂。
Pharmacol Ther. 1984;25(1):83-125. doi: 10.1016/0163-7258(84)90025-1.
4
Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents.
Int J Cancer. 1987 Feb 15;39(2):266-73. doi: 10.1002/ijc.2910390224.
5
The synergistic antitumor effect of natural-human TNF and anticancer drugs.
Hiroshima J Med Sci. 1987 Jun;36(2):157-61.
6
Effect of recombinant human tumor necrosis factor on human nasopharyngeal carcinoma cell line in vitro.重组人肿瘤坏死因子对人鼻咽癌细胞系的体外作用。
Cancer Lett. 1988 Aug 15;41(2):217-24. doi: 10.1016/0304-3835(88)90119-x.
7
Augmentation of cytotoxic activity of recombinant human tumor necrosis factor (rHu-TNF) by recombinant human interferon-gamma (rHu-IFN-gamma).重组人干扰素-γ（rHu-IFN-γ）增强重组人肿瘤坏死因子（rHu-TNF）的细胞毒活性。
J Biol Response Mod. 1987 Dec;6(6):599-609.
8
Therapeutic potential of tumor necrosis factor-alpha and gamma-interferon in experimental human ovarian cancer.
Cancer Res. 1987 Sep 15;47(18):4755-8.
9
In vitro synergistic effects of natural human tumor necrosis factor and natural human interferon-alpha.天然人肿瘤坏死因子与天然人α干扰素的体外协同效应
Jpn J Cancer Res. 1987 Jan;78(1):87-92.
10
In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma.
Int J Cancer. 1986 Nov 15;38(5):763-9. doi: 10.1002/ijc.2910380521.

人重组肿瘤坏死因子α与微管效应物联合的协同细胞毒性

Synergistic cytotoxicity of human recombinant tumour necrosis factor alpha combined with microtubule effectors.

作者信息

Baumgart J, Schlott B, Suehnel J, Vater W, Schulze W, Behnke D

机构信息

Institute of Microbiology and Experimental Therapy, Jena, Federal Republic of Germany.

出版信息

J Cancer Res Clin Oncol. 1991;117(3):239-43. doi: 10.1007/BF01625431.

DOI:10.1007/BF01625431
PMID:2033091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12201880/
Abstract

Combinations of human recombinant tumour necrosis factor alpha (rhTNF alpha) with each of four different agents disturbing the microtubule system of the cellular cytoskeleton were tested for synergistic cytotoxic action against murine melanoma B16K and L-M(S) cells. In addition to the known microtubule effectors colchicine, vincristine, and taxol, the influence of the fluorenone-azo-methine derivative alpha-diphenylene-N-(p-[bis-(beta-hydroxyethyl-amino]-phenyl)- nitrone (DHPN) on the rhTNF alpha cytotoxicity was studied. Applying a novel computer-based isobole method [Suehnel J (1990) Antiviral Res 13:23-40] concentration ranges of synergistic, zero, and antagonistic interaction were found after in vitro combination of rhTNF alpha with each of the drugs tested in a 72-h cytotoxicity assay. In contrast, a 24-h exposure of B16K cells to these combinations still did not inhibit in vitro colony formation to a greater extent than either drug alone. A preliminary in vivo experiment revealed an increased antitumour effect after treatment of established subcutaneous melanoma B16 tumours with a combination of rhTNF alpha and DHPN.

摘要

研究了重组人肿瘤坏死因子α（rhTNFα）与四种不同的破坏细胞骨架微管系统的药物联合使用时，对小鼠黑色素瘤B16K和L-M(S)细胞的协同细胞毒性作用。除了已知的微管效应物秋水仙碱、长春新碱和紫杉醇外，还研究了芴酮-偶氮-甲碱衍生物α-二亚苯基-N-(对-[双-(β-羟乙基-氨基]-苯基)-硝酮（DHPN）对rhTNFα细胞毒性的影响。应用一种新型的基于计算机的等效线法[Suehnel J(1990)Antiviral Res 13:23-40]，在72小时细胞毒性试验中，rhTNFα与每种受试药物体外联合后，发现了协同、无作用和拮抗相互作用的浓度范围。相比之下，B16K细胞在24小时内暴露于这些联合药物中，对体外集落形成的抑制程度仍不大于单独使用任何一种药物。一项初步的体内实验表明，用rhTNFα和DHPN联合治疗已建立的皮下黑色素瘤B16肿瘤后，抗肿瘤效果增强。