Victoria-Gutierrez M, Martinez-Naves E, Coto E, Dominguez O, Uría F, Urra J M, López-Larrea C
Inmunología, Hospital Covadonga, Oviedo, Spain.
J Neuroimmunol. 1991 Jun;32(3):279-83. doi: 10.1016/0165-5728(91)90198-g.
Conversely to the well-established association of DR2/Dw2 with multiple sclerosis (MS) susceptibility in Caucasoids, several studies have found an association of DR4 in populations from Mediterranean origin. We have studied the distribution of the different DR4B1 subtypes in Spanish MS patients. Oligonucleotide probes were selected in order to type samples amplified by polymerase chain reaction (PCR) from Spanish DR4+ MS patients (25) and controls (28). No DR4B1 subtypes were found to be increased in MS. MS susceptibility linked to DR4 may be due to the presence of shared functional epitopes common to the different HLA-DR4B1 subtypes.
与高加索人群中DR2/Dw2与多发性硬化症（MS）易感性之间已确立的关联相反，多项研究发现地中海起源人群中存在DR4关联。我们研究了西班牙MS患者中不同DR4B1亚型的分布情况。选择了寡核苷酸探针，对来自西班牙DR4+ MS患者（25例）和对照（28例）经聚合酶链反应（PCR）扩增的样本进行分型。未发现MS患者中DR4B1亚型增加。与DR4相关的MS易感性可能是由于不同HLA-DR4B1亚型共有的功能性表位所致。
