University of Wisconsin-Madison, School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, USA.
Expert Opin Drug Deliv. 2010 Apr;7(4):429-44. doi: 10.1517/17425241003602259.
The advancement in material design and engineering has led to the rapid development of new materials with increasing complexity and functions. Both non-degradable and degradable polymers have found wide applications in the controlled delivery field. Studies on drug release kinetics provide important information into the function of material systems. To elucidate the detailed transport mechanism and the structure-function relationship of a material system, it is critical to bridge the gap between the macroscopic data and the transport behavior at the molecular level.
The structure and function information of selected non-degradable and degradable polymers have been collected and summarized from literature published after the 1990s. The release kinetics of selected drug compounds from various material systems is discussed in case studies. Recent progress in the mathematical models based on different transport mechanisms is highlighted.
This article aims to provide an overview of structure-function relationships of selected non-degradable and degradable polymers as drug delivery matrices.
Understanding the structure-function relationship of the material system is key to the successful design of a delivery system for a particular application. Moreover, developing complex polymeric matrices requires more robust mathematical models to elucidate the solute transport mechanisms.
材料设计和工程的进步导致了具有越来越复杂和功能的新材料的快速发展。不可降解和可降解聚合物在控制释放领域都有广泛的应用。药物释放动力学的研究为材料系统的功能提供了重要信息。为了阐明材料系统的详细传输机制和结构-功能关系，将宏观数据与分子水平的传输行为联系起来是至关重要的。
从 20 世纪 90 年代以后发表的文献中收集和总结了选定的不可降解和可降解聚合物的结构和功能信息。通过案例研究讨论了各种材料系统中选定药物化合物的释放动力学。强调了基于不同传输机制的数学模型的最新进展。
本文旨在提供选定的不可降解和可降解聚合物作为药物传递基质的结构-功能关系概述。
了解材料系统的结构-功能关系是为特定应用成功设计传递系统的关键。此外，开发复杂的聚合物基质需要更强大的数学模型来阐明溶质传输机制。
