Visan Anita Ioana, Negut Irina
National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, P.O. Box MG 36, 077125 Magurele, Romania.
Polymers (Basel). 2025 Jul 24;17(15):2020. doi: 10.3390/polym17152020.
Polymeric composite thin films have emerged as promising antimicrobial materials, particularly in response to rising antibiotic resistance. This review highlights the development and application of such films produced by laser-based deposition techniques, notably pulsed laser deposition and matrix-assisted pulsed laser evaporation. These methods offer precise control over film composition, structure, and thickness, making them ideal for embedding antimicrobial agents such as metal nanoparticles, antibiotics, and natural compounds into polymeric matrices. The resulting composite coatings exhibit enhanced antimicrobial properties against a wide range of pathogens, including antibiotic-resistant strains, by leveraging mechanisms such as ion release, reactive oxygen species generation, and membrane disruption. The review also discusses critical parameters influencing antimicrobial efficacy, including film morphology, composition, and substrate interactions. Applications include biomedical devices, implants, wound dressings, and surfaces in the healthcare and food industries.
聚合物复合薄膜已成为有前景的抗菌材料，尤其是在应对抗生素耐药性不断上升的情况下。本综述重点介绍了通过基于激光的沉积技术制备的此类薄膜的开发与应用，特别是脉冲激光沉积和基质辅助脉冲激光蒸发。这些方法能够精确控制薄膜的组成、结构和厚度，使其非常适合将金属纳米颗粒、抗生素和天然化合物等抗菌剂嵌入聚合物基质中。通过利用离子释放、活性氧生成和膜破坏等机制，所得的复合涂层对包括耐药菌株在内的多种病原体表现出增强的抗菌性能。该综述还讨论了影响抗菌效果的关键参数，包括薄膜形态、组成和与基材的相互作用。应用领域包括生物医学设备、植入物、伤口敷料以及医疗保健和食品工业中的表面。
