Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville 3010, Australia.
Macromol Rapid Commun. 2013 Jun 13;34(11):894-902. doi: 10.1002/marc.201300093. Epub 2013 May 6.
Click chemistry has had a significant impact in the field of materials science over the last 10 years, as it has enabled the design of new hybrid building blocks, leading to multifunctional and responsive materials. One key application for such materials is in the biomedical field, such as gene or drug delivery. However, to meet the functional requirements of such applications, tailored degradability of these materials under biological conditions is critical. There has been an increasing interest in combining click chemistry techniques with a range of degradable or responsive building blocks as well as investigating new or milder chemistries to design click delivery systems that are capable of physiologically relevant degradation. This Feature Article will cover some of the different approaches to synthesize degradable click delivery systems and their investigation for therapeutic release.
点击化学在过去 10 年中对材料科学领域产生了重大影响，因为它使设计新的杂化构建块成为可能，从而产生多功能和响应性材料。此类材料的一个关键应用是在生物医学领域，例如基因或药物传递。然而，为了满足此类应用的功能要求，在生物条件下对这些材料进行定制降解至关重要。人们越来越感兴趣的是将点击化学技术与一系列可降解或响应性构建块结合使用，以及研究新的或更温和的化学方法来设计能够进行生理相关降解的点击传递系统。本文将介绍一些合成可降解点击传递系统的不同方法及其用于治疗性释放的研究。
