Nencki Institute of Experimental Biology, Pasteura 3 Street, 02-093 Warsaw, Poland.
Traffic. 2010 Jun;11(6):721-31. doi: 10.1111/j.1600-0854.2010.01061.x. Epub 2010 Mar 17.
Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.
Ruk/CIN85 是一种衔接蛋白。与许多其他类型的蛋白质一样，Ruk/CIN85 已知参与多种细胞过程，包括信号转导、囊泡介导的运输、细胞骨架重塑、程序性细胞死亡和病毒感染。最近的研究还揭示了 Ruk/CIN85 在癌细胞侵袭性中的潜在重要性。在这篇综述中，我们总结了该蛋白的各种作用，以及 Ruk/CIN85 对恶性肿瘤和癌细胞侵袭性的潜在贡献。在本文的最后一节，我们还推测了 Ruk/CIN85 作为新型抗癌疗法的靶标是否具有实用性。
