Montjean Debbie, Ménézo Yves, Benkhalifa Moncef, Cohen Marc, Belloc Stephanie, Cohen-Bacrie Paul, de Mouzon Jacques
ATL, R & D, 78320 La Verriere, France.
Zygote. 2010 Aug;18(3):265-8. doi: 10.1017/S0967199409990311. Epub 2010 Mar 24.
Malondialdehyde (MDA), a product involved in membrane lipid peroxidation, was dosed in the sperm of 163 patients who had consulted the clinic regarding hypofertility. We attempted to determine if there was correlation between MDA content, sperm World Health Organization parameters and DNA fragmentation that results mainly from reactive oxygen species assaults. We found that no correlation could be established; however MDA and sperm decondensation were shown to be significantly linked. The impact of membrane polyunsaturated fatty acids and the role of phospholipid hydroperoxide glutathione peroxidase are discussed.
丙二醛（MDA）是一种参与膜脂质过氧化的产物，我们对163名因生育能力低下前来门诊咨询的患者的精子进行了MDA检测。我们试图确定MDA含量、精子世界卫生组织参数以及主要由活性氧攻击导致的DNA片段化之间是否存在关联。我们发现无法建立相关性；然而，MDA与精子解聚之间显示出显著关联。文中讨论了膜多不饱和脂肪酸的影响以及磷脂氢过氧化物谷胱甘肽过氧化物酶的作用。
