University Hospital Freiburg, Department of Psychiatry and Psychotherapy, Hauptstr. 5, D-79104 Freiburg, Germany.
J Psychiatr Res. 2010 Oct;44(14):938-43. doi: 10.1016/j.jpsychires.2010.02.016. Epub 2010 Mar 23.
Neurobiological research has implicated the cerebellum as one possible site of neurophysiological dysfunction in ADHD. Latest theoretical conceptualizations of the cerebellum as core site of the brain to model motor as well as cognitive behavior puts further weight to the assumption that it might play a key role in ADHD pathophysiology.
30 medication free adult ADHD patients and 30 group matched (gender, age and education) healthy controls were investigated using the method of chemical shift imaging (CSI) of the cerebellum. The vermis, left and right cerebellar hemispheres were processed separately.
We found significantly increased glutamate-glutamine (Glx) to creatine (Cre) ratios in the left cerebellar hemisphere. No other differences in measured metabolite concentrations were observed.
To our knowledge this is the first evidence for neurochemical alterations in cerebellar neurochemistry in adult ADHD. They relate well to recent hypotheses that the cerebellum might control mental activities by internal models.
神经生物学研究表明，小脑可能是 ADHD 神经生理功能障碍的一个潜在部位。最新的小脑作为大脑核心部位的理论概念，用于模拟运动和认知行为，进一步证明了小脑可能在 ADHD 病理生理学中发挥关键作用。
我们使用小脑的化学位移成像（CSI）方法对 30 名未服药的成年 ADHD 患者和 30 名性别、年龄和教育程度匹配的健康对照组进行了研究。单独处理蚓部、左侧和右侧小脑半球。
我们发现左小脑半球的谷氨酸-谷氨酰胺（Glx）与肌酸（Cre）比值显著增加。未观察到其他代谢物浓度的差异。
据我们所知，这是成人 ADHD 小脑神经化学改变的首个证据。它们与最近的假设密切相关，即小脑可能通过内部模型来控制精神活动。
