Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
J Am Soc Mass Spectrom. 2010 Jul;21(7):1118-21. doi: 10.1016/j.jasms.2010.02.019. Epub 2010 Feb 18.
High field asymmetric waveform ion mobility spectrometry (FAIMS) has been used increasingly in recent years as an additional method of ion separation and selection before mass spectrometry. The FAIMS electrodes are relatively simple to design and fabricate for laboratories wishing to implement their own FAIMS designs. However, construction of the electronics apparatus needed to produce the required high magnitude asymmetric electric field oscillating at a frequency of several hundred kilohertz is not trivial. Here we present an entirely custom-built electronics setup capable of supplying the required waveforms and voltages. The apparatus is relatively simple and inexpensive to implement. We also present data acquired on this system demonstrating the use of FAIMS as a gas-phase ion filter interface to an ion trap mass spectrometer.
高场非对称波形离子迁移谱（FAIMS）近年来已越来越多地被用作质谱前离子分离和选择的附加方法。对于希望实施自己的 FAIMS 设计的实验室而言，FAIMS 电极相对易于设计和制造。然而，构建用于产生所需的高幅度不对称电场的电子设备并不简单，该电场以数百千赫兹的频率振荡。在这里，我们展示了一个完全定制的电子设备，能够提供所需的波形和电压。该设备的实现相对简单且价格低廉。我们还展示了在此系统上获得的数据，证明了 FAIMS 作为气相离子过滤接口与离子阱质谱仪联用的用途。
