丙型肝炎病毒感染与生物性梅毒血清假阳性反应。
Hepatitis C virus infection and biological false-positive syphilis tests.
机构信息
SUNY Downstate Medical Center, Brooklyn, New York 11203, USA.
出版信息
Sex Transm Infect. 2010 Apr;86(2):97-8. doi: 10.1136/sti.2009.040360.
BACKGROUND
The diagnosis of syphilis requires two-step serological testing. Not infrequently, sensitive screening tests are reactive but are not confirmed by more specific confirmatory tests yielding a biological false positive (BFP). This study sought to describe the prevalence of BFP in a large population of hepatitis C virus (HCV)-infected and uninfected women.
METHODS
A cross-sectional serosurvey of HIV-seropositive and HIV-seronegative women enrolled in the Women's Interagency HIV Study, a multicentre collaborative study of the natural history of HIV in women.
RESULTS
Among HCV-infected women 4% had a BFP compared with 1% among those who were HCV uninfected (odds ratio (OR) 3.3, 95% CI 2.1 to 5.1). Controlling for both HIV infection and a history of intravenous drug use among all tests for syphilis a BFP also occurred more commonly in HCV-infected women compared with HCV-uninfected women (6% vs 1%, OR 7.62, 95% CI 1.9 to 12.5).
CONCLUSION
HCV infection is associated with various effects on immune function including alterations in serological test results. Women with HCV are more likely to have a BFP syphilis test than women without HCV.
背景
梅毒的诊断需要两步血清学检测。敏感的筛查试验经常出现反应性，但不能被更特异的确认试验所证实，从而导致生物学假阳性（BFP）。本研究旨在描述在大量丙型肝炎病毒（HCV）感染和未感染的妇女中 BFP 的流行率。
方法
对参加妇女艾滋病病毒研究机构间艾滋病毒研究（Women's Interagency HIV Study）的 HIV 阳性和 HIV 阴性妇女进行了横断面血清学调查，这是一项关于 HIV 在妇女中的自然史的多中心合作研究。
结果
在 HCV 感染的妇女中，4%有 BFP，而 HCV 未感染的妇女中为 1%（比值比（OR）3.3，95%置信区间 2.1 至 5.1）。在所有梅毒检测中，控制 HIV 感染和静脉吸毒史后，HCV 感染的妇女与 HCV 未感染的妇女相比，BFP 也更常见（6%比 1%，OR 7.62，95%置信区间 1.9 至 12.5）。
结论
HCV 感染与包括血清学检测结果改变在内的各种免疫功能的影响有关。与没有 HCV 的妇女相比，有 HCV 的妇女更有可能出现梅毒 BFP 检测阳性。
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