Pathology Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia.
Anticancer Res. 2010 Feb;30(2):641-4.
The clinical and pathological features of multiple different renal neoplasms arising in a setting of end-stage renal disease in a 72-year-old male are described. The kidney showed features of renal oncocytosis with multiple oncocytomas, hybrid tumours and chromophobe renal carcinoma. In addition, the kidney contained a type 2 papillary renal cell carcinoma, clear cell papillary and cystic renal cell carcinoma, and tubulocystic carcinoma. The occurrence of these three tumours in a setting of end-stage kidney disease is unique and suggests a common pathogenesis. Immunostaining of these tumours further suggests they are derived from similar stem cells which show immunophenotypic features of both the proximal and distal nephron.
本文描述了一例 72 岁男性终末期肾病背景下多种不同肾肿瘤的临床和病理特征。肾脏表现为肾嗜酸细胞瘤特征，有多个嗜酸细胞瘤、杂交性肿瘤和嫌色细胞癌。此外，肾脏还包含 2 型乳头状肾细胞癌、透明细胞乳头状和囊性肾细胞癌以及管状囊性癌。这三种肿瘤在终末期肾病背景下的同时发生是独特的，并提示其具有共同的发病机制。这些肿瘤的免疫组化染色进一步提示它们来源于相似的干细胞，这些干细胞表现出近端和远端肾单位的免疫表型特征。
