Marwaha Raman K, Garg M K, Bhadra Kuntal, Tandon Nikhil
Senior Consultant Endocrinology and Scientific Advisor (Projects), ILSI-India, New Delhi, India.
Commandant and Consultant, Department of Medicine and Endocrinology, Military Hospital, Shillong, Meghalaya, India.
Indian J Endocrinol Metab. 2015 Sep-Oct;19(5):608-15. doi: 10.4103/2230-8210.163174.
There are conflicting reports on the relationship of lean mass (LM) and fat mass (FM) with bone mineral content (BMC). Given the high prevalence of Vitamin D deficiency in India, we planned the study to evaluate the relationship between LM and FM with BMC in Indian children and adolescents. The objective of the study was to evaluate the relationship of BMC with LM and FM.
Total and regional BMC, LM, and FM using dual energy X-ray absorptiometry and pubertal staging were assessed in 1403 children and adolescents (boys [B]: 826; girls [G]: 577). BMC index, BMC/LM and BMC/FM ratio, were calculated.
The age ranged from 5 to 18 years, with a mean age of 13.2 ± 2.7 years. BMC adjusted for height (BMC index and BMC/height ratio) was comparable in both genders. There was no difference in total BMC between genders in the prepubertal group but were higher in more advanced stages of pubertal maturation. The correlation of total as well as regional BMC was stronger for LM (B: Total BMC - 0.880, trunk - 0.715, leg - 0.894, arm - 0.891; G: Total BMC - 0.827, leg - 0.846, arm - 0.815 (all value indicate r (2), P < 0.0001 for all) when compared with FM (B: Total BMC - 0.776, trunk - 0.676, leg - 0.772, arm - 0.728; G: Total BMC - 0.781, leg - 0.741, arm - 0.689; all P < 0.0001) except at trunk BMC (LM - 0.682 vs. FM - 0.721; all P < 0.0001), even after controlling for age, height, pubertal stage, and biochemical parameters.
BMC had a stronger positive correlation with LM than FM.
关于瘦体重（LM）和脂肪量（FM）与骨矿物质含量（BMC）之间的关系，存在相互矛盾的报道。鉴于印度维生素D缺乏的高患病率，我们计划开展这项研究，以评估印度儿童和青少年中LM和FM与BMC之间的关系。该研究的目的是评估BMC与LM和FM之间的关系。
采用双能X线吸收法对1403名儿童和青少年（男孩[B]：826名；女孩[G]：577名）的全身和局部BMC、LM和FM以及青春期分期进行评估。计算BMC指数、BMC/LM和BMC/FM比值。
年龄范围为5至18岁，平均年龄为13.2±2.7岁。经身高调整后的BMC（BMC指数和BMC/身高比值）在两性中相当。青春期前组两性的全身BMC无差异，但在青春期成熟的更高级阶段更高。与FM相比，全身以及局部BMC与LM的相关性更强（男孩：全身BMC - 0.880，躯干 - 0.715，腿部 - 0.894，手臂 - 0.891；女孩：全身BMC - 0.827，腿部 - 0.846，手臂 - 0.815（所有值均表示r(2)，所有P < 0.0001）），而FM（男孩：全身BMC - 0.776，躯干 - 0.676，腿部 - 0.772，手臂 - 0.728；女孩：全身BMC - 0.781，腿部 - 0.741，手臂 - 0.689；所有P < 0.0001），除了躯干BMC（LM - 0.682对FM - 0.721；所有P < 0.0001），即使在控制了年龄、身高、青春期阶段和生化参数之后也是如此。
BMC与LM的正相关性比与FM更强。
