Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.
J Neurol. 2010 Jun;257(6):882-97. doi: 10.1007/s00415-010-5517-4. Epub 2010 Mar 24.
Huntington's disease (HD) is a fatal neurodegenerative disease caused by an abnormal expansion of a CAG repeat in exon 1 of the HD gene on chromosome 4. The disease runs a debilitating and progressive course with an average survival of 15-25 years after disease onset. HD patients classically develop involuntary movements including chorea, as well as progressive cognitive and psychiatric disturbances, although a number of other features have also been reported, including changes in sleep and circadian rhythms; it is this latter area that forms the focus of this review.
亨廷顿病（HD）是一种致命的神经退行性疾病，由 HD 基因第 1 外显子中 CAG 重复序列异常扩展引起。该疾病呈进行性恶化，平均发病后 15-25 年后患者死亡。HD 患者经典地表现出不自主运动，包括舞蹈症，以及进行性认知和精神障碍，尽管也报道了许多其他特征，包括睡眠和昼夜节律的变化；正是后者成为本综述的重点。
