• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.

作者信息

Veleiro Adriana S, Alvarez Lautaro D, Eduardo Silvina L, Burton Gerardo

机构信息

Departamento de Química Orgánica and UMYMFOR, Universidad de Buenos Aires, Argentina.

出版信息

ChemMedChem. 2010 May 3;5(5):649-59. doi: 10.1002/cmdc.201000014.

DOI:10.1002/cmdc.201000014
PMID:20333619
Abstract
摘要

相似文献

1
Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.
ChemMedChem. 2010 May 3;5(5):649-59. doi: 10.1002/cmdc.201000014.
2
X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.新型增强亲和力糖皮质激素激动剂糠酸氟替卡松在糖皮质激素受体-配体结合域中的X射线晶体结构
J Med Chem. 2008 Jun 26;51(12):3349-52. doi: 10.1021/jm800279t. Epub 2008 Jun 4.
3
Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations.糖皮质激素受体中的分子开关：活性和被动拮抗剂构象。
J Mol Biol. 2010 Jan 22;395(3):568-77. doi: 10.1016/j.jmb.2009.11.011. Epub 2009 Nov 11.
4
Rational structure-based drug design and optimization in the ligand-binding domain of the glucocorticoid receptor-α.基于理性结构的糖皮质激素受体-α配体结合域药物设计与优化。
Future Med Chem. 2009 May;1(2):345-59. doi: 10.4155/fmc.09.21.
5
Mixed-model QSAR at the glucocorticoid receptor: predicting the binding mode and affinity of psychotropic drugs.糖皮质激素受体的混合模型定量构效关系：预测精神药物的结合模式和亲和力。
ChemMedChem. 2009 Jan;4(1):100-9. doi: 10.1002/cmdc.200800274.
6
Conformational states of the glucocorticoid receptor DNA-binding domain from molecular dynamics simulations.基于分子动力学模拟的糖皮质激素受体DNA结合结构域的构象状态
Proteins. 2002 Oct 1;49(1):24-36. doi: 10.1002/prot.10195.
7
Structure and function of the glucocorticoid receptor ligand binding domain.糖皮质激素受体配体结合域的结构与功能
Vitam Horm. 2004;68:49-91. doi: 10.1016/S0083-6729(04)68002-2.
8
Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" method.通过应用“协同对接”方法设计与合成新型非甾体糖皮质激素调节剂
J Med Chem. 2005 Jul 14;48(14):4507-10. doi: 10.1021/jm050345y.
9
Drug insight: selective agonists and antagonists of the glucocorticoid receptor.药物洞察：糖皮质激素受体的选择性激动剂和拮抗剂
Nat Clin Pract Endocrinol Metab. 2008 Feb;4(2):91-101. doi: 10.1038/ncpendmet0745.
10
Induced-fit docking of mometasone furoate and further evidence for glucocorticoid receptor 17alpha pocket flexibility.糠酸莫米松的诱导契合对接及糖皮质激素受体17α口袋灵活性的进一步证据
J Mol Graph Model. 2008 Nov;27(4):512-21. doi: 10.1016/j.jmgm.2008.09.002. Epub 2008 Sep 10.

引用本文的文献

1
The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor.双黄酮阿盖黄酮通过糖皮质激素受体调节小胶质细胞和星形胶质细胞的炎症特征。
Molecules. 2025 Feb 22;30(5):1014. doi: 10.3390/molecules30051014.
2
Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues.配体结合域中的糖皮质激素受体通道扩张有助于高效糖皮质激素类似物的活性。
Molecules. 2024 Mar 29;29(7):1546. doi: 10.3390/molecules29071546.
3
Skin Anti-Inflammatory Potential with Reduced Side Effects of Novel Glucocorticoid Receptor Agonists.
新型糖皮质激素受体激动剂具有降低的皮肤抗炎副作用潜力。
Int J Mol Sci. 2023 Dec 23;25(1):267. doi: 10.3390/ijms25010267.
4
Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.四级糖皮质激素受体结构突显了变构域间通讯。
Nat Struct Mol Biol. 2023 Mar;30(3):286-295. doi: 10.1038/s41594-022-00914-4. Epub 2023 Feb 6.
5
The Role of Conformational Dynamics and Allostery in the Control of Distinct Efficacies of Agonists to the Glucocorticoid Receptor.构象动力学和变构作用在控制激动剂对糖皮质激素受体不同效能中的作用
Front Mol Biosci. 2022 Jul 7;9:933676. doi: 10.3389/fmolb.2022.933676. eCollection 2022.
6
Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis.通过分子动力学模拟和马科夫状态模型分析发现新型糖皮质激素受体配体，针对可药物化的糖皮质激素受体拮抗剂构象。
Adv Sci (Weinh). 2022 Jan;9(3):e2102435. doi: 10.1002/advs.202102435. Epub 2021 Nov 26.
7
Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor.指导糖皮质激素受体差异激活的动态变构通讯途径
Sci Adv. 2020 Jul 17;6(29):eabb5277. doi: 10.1126/sciadv.abb5277. eCollection 2020 Jul.
8
Exploring the binding properties of agonists interacting with glucocorticoid receptor: an in silico approach.探索激动剂与糖皮质激素受体相互作用的结合特性：一种计算机模拟方法。
J Mol Model. 2018 Nov 20;24(12):342. doi: 10.1007/s00894-018-3879-1.
9
A Quantitative Study of Internal and External Interactions of Homodimeric Glucocorticoid Receptor Using Fluorescence Cross-Correlation Spectroscopy in a Live Cell.使用活细胞中的荧光相关光谱技术对同型二聚体糖皮质激素受体的内部和外部相互作用进行定量研究。
Sci Rep. 2017 Jun 28;7(1):4336. doi: 10.1038/s41598-017-04499-7.
10
Structure of a 13-fold superhelix (almost) determined from first principles.从第一性原理出发确定的 13 重超螺旋结构（几乎）。
IUCrJ. 2015 Jan 27;2(Pt 2):177-87. doi: 10.1107/S2052252515000238. eCollection 2015 Mar 1.