Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
J Psychiatr Res. 2010 Oct;44(14):986-8. doi: 10.1016/j.jpsychires.2010.02.015. Epub 2010 Mar 23.
Despite a large proportion of smoker in Chinese population, few studies address the prevalence of smoking in schizophrenia in such a homogeneous ethnic group. This study examined gender-specific relationships between smoking and schizophrenia, which have previously received little systematic study. The prevalence of smoking in 510 inpatients with schizophrenia and 793 normal controls was evaluated. The relationships between smoking and retrospectively assessed measures of the course of schizophrenia were evaluated by clinician-administered questionnaires. The results showed that the gender difference in smoking prevalence was in the opposite direction for males compared to females between schizophrenia and normal controls. Male patients had a higher smoking rate than controls (81% vs 66%, adjusted OR = 2.3, p < 0.0001), while female patients had a lower rate than controls (5% vs 9% p > 0.05). Smoking was associated with a family history of smoking, a personal history of alcohol use and age in men with schizophrenia. Our present findings suggest a significant gender difference in the prevalence of smoking in schizophrenia.
尽管中国人口中有很大一部分是烟民，但很少有研究针对这种同一种族群体中的精神分裂症患者吸烟流行率进行研究。本研究旨在探讨吸烟与精神分裂症之间的性别特异性关系，这方面的研究此前很少有系统地进行过。本研究评估了 510 名精神分裂症住院患者和 793 名正常对照者的吸烟流行率。通过临床医生管理的问卷评估了吸烟与精神分裂症病程的回顾性评估指标之间的关系。结果表明，与女性相比，男性精神分裂症患者与正常对照组之间的吸烟流行率差异方向相反。男性患者的吸烟率高于对照组（81%对 66%，调整后的 OR=2.3，p<0.0001），而女性患者的吸烟率低于对照组（5%对 9%，p>0.05）。吸烟与精神分裂症男性患者的家族吸烟史、酒精使用史和年龄有关。我们目前的研究结果表明，精神分裂症患者的吸烟流行率存在显著的性别差异。
