Brain Research Centre and Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
Learn Mem. 2010 Mar 24;17(4):191-201. doi: 10.1101/lm.960510. Print 2010 Apr.
This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.
这篇文章综述了土壤线虫秀丽隐杆线虫的学习和记忆方面的文献。研究范式包括非联想学习、联想学习和印痕学习，因为已经证明线虫可以习惯机械和化学刺激，并且可以学习气味、味道、温度和氧气水平，这些可以预测厌恶的化学物质或食物的存在与否。在每种情况下，行为的神经回路至少部分被描述，正向和反向遗传学被用来阐明潜在的细胞和分子机制。已经鉴定出几个基因，除了介导行为可塑性外，它们没有已知的作用。
